Varaico: Literature-Extracted Genetic Variants

Gene:PGR
Variant:p.V660L
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PGR

NM_000926.4:p.V660L

Associated Papers

Molecular analysis of the evolutionary history of endometrial and ovarian carcinoma in Lynch syndrome.

Kauppinen AK et al.

International Journal of Cancer, 2025

40772756 (PubMed )
Supplement: IJC-157-2294-s002.xlsx › B_Tissue_as_normal

Genomic landscape of hormone therapy-resistant HR-positive, HER2-negative breast cancer.

Chaubal R et al.

Breast Cancer Research and Treatment, 2025

40652157 (PubMed )
Supplement: 10549_2025_7759_MOESM4_ESM.xlsx › stable9

Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review.

Tsinopoulou VR et al.

Hormones (athens, Greece), 2025

Combining germline, tissue and liquid biopsy analysis by comprehensive genomic profiling to improve the yield of actionable variants in a real-world cancer cohort.

Vanni I et al.

Journal of Translational Medicine, 2024

38750555 (PubMed )
Supplement: 12967_2024_5227_MOESM14_ESM.xlsx › S14

Association between XRCC2 Arg188His Polymorphism and Breast Cancer Susceptibility: A Systematic Review and Meta-Analysis.

Dastgheib SA et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2024

Gene variants polymorphisms and uterine leiomyoma: an updated review.

Upadhyay S et al.

Frontiers in Genetics, 2024

Association of Val660Leu, progesterone receptor polymorphic variant, with susceptibility to RRMS disease.

Salimian M et al.

Neurological Research, 2023

Progesterone Receptor Gene Polymorphisms and Breast Cancer Risk.

Vang A et al.

Endocrinology, 2023

Molecular determination of progesterone receptor's PROGINS allele (Alu insertion) and its association with the predisposition and susceptibility to polycystic ovary syndrome (PCOS).

Mir R et al.

Mammalian Genome : Official Journal of the International Mammalian Genome Society, 2022

Progesterone receptor genetic variants in pregnant women and fetuses as possible predictors of spontaneous premature birth: A preliminary case-control study.

Kadivnik M et al.

The Journal of Obstetrics and Gynaecology Research, 2022

Genetic Factors of Idiopathic Gigantomastia: Clinical Implications of Aromatase and Progesterone Receptor Polymorphisms.

Kasielska-Trojan A et al.

Journal of Clinical Medicine, 2022

Association of the PROGINS PgR polymorphism with susceptibility to female reproductive cancer: A meta-analysis of 30 studies.

Zhou C et al.

Plos One, 2022

Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth.

Huusko JM et al.

Scientific Reports, 2021

Why does SARS-CoV-2 hit in different ways? Host genetic factors can influence the acquisition or the course of COVID-19.

Monticelli M et al.

European Journal of Medical Genetics, 2021

33872774 (PubMed )
Supplement: mmc2.xlsx › Foglio1

The Neandertal Progesterone Receptor.

Zeberg H et al.

Molecular Biology and Evolution, 2020

Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer.

Montazeri Z et al.

Gut, 2020

31818908 (PubMed )
Supplement: gutjnl-2019-319313supp003.pdf

Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer.

Fowler AM et al.

Hormones & Cancer, 2020

Steroid hormone-related polymorphisms associate with the development of bone erosions in rheumatoid arthritis and help to predict disease progression: Results from the REPAIR consortium.

Sánchez-Maldonado JM et al.

Scientific Reports, 2019

Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients.

Canet LM et al.

The Pharmacogenomics Journal, 2019

Natural Selection Has Differentiated the Progesterone Receptor among Human Populations.

Li J et al.

American Journal of Human Genetics, 2018

Genetic variation in the progesterone receptor gene and susceptibility to recurrent pregnancy loss: a case-control study.

Bahia W et al.

Bjog : an International Journal of Obstetrics and Gynaecology, 2018

A mutation in the progesterone receptor predisposes to HEV infection in HIV-positive patients.

Debes JD et al.

Liver International : Official Journal of the International Association for the Study of the Liver, 2018

Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss.

Arias-Sosa LA et al.

Journal of Assisted Reproduction and Genetics, 2018

Mitochondrial determinants of cancer health disparities.

Choudhury AR et al.

Seminars in Cancer Biology, 2017

Frequency of Alu insertions within the ACE and PR loci in Northwestern Mexicans.

Navarrete HP et al.

Bmc Research Notes, 2017

Investigation of DNA repair-related SNPs underlying susceptibility to papillary thyroid carcinoma reveals MGMT as a novel candidate gene in Belarusian children exposed to radiation.

Lonjou C et al.

Bmc Cancer, 2017

28499365 (PubMed )
Supplement: 12885_2017_3314_MOESM1_ESM.xls › SupplTableS1.xls

An exploratory study of host polymorphisms in genes that clinically characterize breast cancer tumors and pretreatment cognitive performance in breast cancer survivors.

Koleck TA et al.

Breast Cancer (dove Medical Press), 2017

Novel near-diploid ovarian cancer cell line derived from a highly aneuploid metastatic ovarian tumor.

Rozenblum E et al.

Plos One, 2017

28787462 (PubMed )
Supplement: pone.0182610.s001.xlsx › H1-Ea-La_mut

Progesterone receptor gene (PROGINS) polymorphism correlates with late onset of migraine.

Palmirotta R et al.

Dna and Cell Biology, 2015

Polymorphisms of progesterone receptor and ovarian cancer risk: a systemic review and meta-analysis.

Liao J et al.

The Journal of Obstetrics and Gynaecology Research, 2015

Genetic polymorphisms and gene-dosage effect in ovarian cancer risk and response to paclitaxel/cisplatin chemotherapy.

Tecza K et al.

Journal of Experimental & Clinical Cancer Research : Cr, 2015

A steroid metabolizing gene variant in a polyfactorial model improves risk prediction in a high incidence breast cancer population.

Jupe ER et al.

Bba Clinical, 2014

26673457 (PubMed )
Supplement: mmc1.pdf

Association of the progesterone receptor gene polymorphism (PROGINS) with endometriosis: a meta-analysis.

Pabalan N et al.

Archives of Gynecology and Obstetrics, 2014

Progesterone receptor PROGINS and +331G/A polymorphisms confer susceptibility to ovarian cancer: a meta-analysis based on 17 studies.

Liu T et al.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2014

Hybrid curation of gene-mutation relations combining automated extraction and crowdsourcing.

Burger JD et al.

Database : the Journal of Biological Databases and Curation, 2014

25246425 (PubMed )
Supplement: supp_bau094_Appendix_D_v30.docx

Analyze association of the progesterone receptor gene polymorphism PROGINS with ovarian cancer risk.

Yuan C et al.

Molecular Biology Reports, 2013

Association of progesterone receptor gene polymorphism with male infertility and clinical outcome of ICSI.

Sen S et al.

Journal of Assisted Reproduction and Genetics, 2013

Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer.

Lundin E et al.

Cancer Epidemiology, 2012

Progesterone receptor variants associated with the PROGINS haplotype exhibit functional properties similar to those of wild-type progesterone receptor.

Stenzig J et al.

Pharmacogenetics and Genomics, 2012

Role of common genetic variants in ovarian cancer susceptibility and outcome: progress to date from the Ovarian Cancer Association Consortium (OCAC).

Bolton KL et al.

Journal of Internal Medicine, 2012

[Correlation of polymorphism rs1563828 in MDM4 gene with breast cancer risk and onset age].

Song CG et al.

Zhonghua Wai Ke Za Zhi [chinese Journal of Surgery], 2012

Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2.

Kirchhoff T et al.

Plos One, 2012

22768030 (PubMed )
Supplement: pone.0035706.s002.doc

Significant role of estrogen and progesterone receptor sequence variants in gallbladder cancer predisposition: a multi-analytical strategy.

Srivastava A et al.

Plos One, 2012

Association analysis between variants in bovine progesterone receptor gene and superovulation traits in Chinese Holstein cows.

Yang WC et al.

Reproduction in Domestic Animals = Zuchthygiene, 2011

Association of sex hormone receptor gene polymorphisms with recurrent pregnancy loss: a systematic review and meta-analysis.

Su MT et al.

Fertility and Sterility, 2011

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