Varaico: Literature-Extracted Genetic Variants

Gene:PIK3CA
Variant:p.P124L
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PIK3CA

NM_006218.4:p.P124L

Associated Papers

Concurrent genomic assessment of circulating tumour cells and ctDNA to guide therapy in metastatic breast cancer.

Allsopp RC et al.

Bmc Cancer, 2025

41351070 (PubMed )
Supplement: 12885_2025_15187_MOESM1_ESM.zip › Supp_Table_1.xlsx › Sheet1

Identification of Somatic Genetic Variants in Superficial Vascular Malformations by Liquid Biopsy in a Cohort of 88 Patients from a French Hospital.

El Sissy FN et al.

Molecular Diagnosis & Therapy, 2025

Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States.

George SL et al.

Cancer Discovery, 2025

39693475 (PubMed )
Supplement: cd-24-0916_supplementary_table_5_suppst5.xlsx › Sheet1

Case report: Dramatic impact of DNA next generation sequencing results using specific targeted therapies-ALK and PIK3CA.

Cullum S et al.

Frontiers in Oncology, 2024

Case Report: Primary Pleural Angiosarcoma in a Patient With Klippel-Trenaunay Syndrome.

Xu J et al.

Frontiers in Genetics, 2022

Clinical Validation of Whole Genome Sequencing for Cancer Diagnostics.

Roepman P et al.

The Journal of Molecular Diagnostics : Jmd, 2021

Molecular Characterization of Astrocytoma Progression Towards Secondary Glioblastomas Utilizing Patient-Matched Tumor Pairs.

Seifert M et al.

Cancers, 2020

32604718 (PubMed )
Supplement: cancers-12-01696-s001.zip › Supporting_Tables_and_Figures › Table_S8_ExomeSeq_Predictions.xlsx › MuTect_SNV_Predictions

The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research.

Painter CA et al.

Nature Medicine, 2020

Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Brown AL et al.

Plos Computational Biology, 2019

31034466 (PubMed )
Supplement: pcbi.1006981.s010.xlsx › final_benchmark

The identification of patient-specific mutations reveals dual pathway activation in most patients with melanoma and activated receptor tyrosine kinases in BRAF/NRAS wild-type melanomas.

Appenzeller S et al.

Cancer, 2019

The prognostic effects of somatic mutations in ER-positive breast cancer.

Griffith OL et al.

Nature Communications, 2018

30181556 (PubMed )
Supplement: 41467_2018_5914_MOESM6_ESM.xlsx › Combined_All

The Phosphatidylinositol 3-Kinase Pathway as a Potential Therapeutic Target in Bladder Cancer.

Zeng SX et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2017

PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma.

Ross RL et al.

Bmc Cancer, 2016

Comprehensive genomic profiling of 295 cases of clinically advanced urothelial carcinoma of the urinary bladder reveals a high frequency of clinically relevant genomic alterations.

Ross JS et al.

Cancer, 2016

Mutant PIK3CA controls DUSP1-dependent ERK 1/2 activity to confer response to AKT target therapy.

Sathe A et al.

British Journal of Cancer, 2014

PIK3CA mutation spectrum in urothelial carcinoma reflects cell context-dependent signaling and phenotypic outputs.

Ross RL et al.

Oncogene, 2013

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer.

Knowles MA et al.

Cancer Metastasis Reviews, 2009

Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer.

Platt FM et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2009

Novel genomic prognostic biomarkers for dogs with cancer.

Chon E et al.

Journal of Veterinary Internal Medicine, 0

37801037 (PubMed )
Supplement: JVIM-37-2410-s001.xlsx › Supp._Table_1
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."