Varaico: Literature-Extracted Genetic Variants

Gene:PIK3CA
Variant:p.R335*
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PIK3CA

NM_006218.4:p.R335*

Associated Papers

A prospective, multicenter, comprehensive genomic profile signature study in patients with EGFR-mutant advanced non-small cell lung cancer at the first-line treatment failure of osimertinib.

Shi Y et al.

Signal Transduction and Targeted Therapy, 2025

41326340 (PubMed )
Supplement: 41392_2025_2481_MOESM1_ESM.docx

PTEN hamartoma of soft tissue (PHOST) and fibroadipose vascular anomaly (FAVA): a comparative clinicopathologic and molecular analysis.

Xue S et al.

Virchows Archiv : an International Journal of Pathology, 2025

A De Novo PTEN Pathogenic Variant in a Young Girl with Sporadic Cowden Syndrome-A Case Report.

Gebhart P et al.

Pediatric Reports, 2025

Metastatic Plasmacytoid Bladder Cancer Harboring a CDH-1 Mutation and Producing High Levels of CA 19-9. A Case Report and Literature Review.

Telfah M et al.

The American Journal of Case Reports, 2020

Targeting the PI3-kinase pathway in triple-negative breast cancer.

Pascual J et al.

Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2019

Prevalence and spectrum of AKT1, PIK3CA, PTEN and TP53 somatic mutations in Chinese breast cancer patients.

Li G et al.

Plos One, 2018

Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies.

Xiu J et al.

Oncotarget, 2016

26933808 (PubMed )
Supplement: oncotarget-07-21556-s001.pdf

Comprehensive genomic profiling of 295 cases of clinically advanced urothelial carcinoma of the urinary bladder reveals a high frequency of clinically relevant genomic alterations.

Ross JS et al.

Cancer, 2016

Mutations in PI3K/AKT pathway genes and amplifications of PIK3CA are associated with patterns of recurrence in gastric cancers.

Fang WL et al.

Oncotarget, 2016

26701847 (PubMed )
Supplement: oncotarget-07-6201-s001.pdf

AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake.

Rashmi R et al.

Plos One, 2014

The determinants of head and neck cancer: Unmasking the PI3K pathway mutations.

Giudice FS et al.

Journal of Carcinogenesis & Mutagenesis, 2013

Cowden syndrome-related mutations in PTEN associate with enhanced proteasome activity.

He X et al.

Cancer Research, 2013

Mutations of the human PTEN gene.

Bonneau D et al.

Human Mutation, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."