Varaico: Literature-Extracted Genetic Variants

Gene:PIK3CA
Variant:p.E525K
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PIK3CA

NM_006218.4:p.E525K

Associated Papers

The constitutive oncogenic and signaling activities of phosphatidylinositol 3-kinase (PI3K) isoforms p110β and p110δ.

Ito Y et al.

Biorxiv : the Preprint Server for Biology, 2025

Molecular Basis of Oncogenic PI3K Proteins.

Sheng Z et al.

Cancers, 2024

Clinical, Immunological, and Genetic Features in Patients with Activated PI3Kδ Syndrome (APDS): a Systematic Review.

Jamee M et al.

Clinical Reviews in Allergy & Immunology, 2020

Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients.

Chen L et al.

Nature Communications, 2018

Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases.

Dornan GL et al.

Frontiers in Immunology, 2018

Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1.

Dornan GL et al.

Proceedings of the National Academy of Sciences of the United States of America, 2017

Primary Immunodeficiencies Associated with EBV Disease.

Cohen JI

Current Topics in Microbiology and Immunology, 2015

Phosphatidylinositol-3-kinase α catalytic subunit gene somatic mutations in bronchopulmonary neuroendocrine tumours.

Capodanno A et al.

Oncology Reports, 2012

Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer.

Ellis MJ et al.

Breast Cancer Research and Treatment, 2010

Activated PI3K-delta syndrome in an Egyptian pediatric cohort with primary immune deficiency.

Ahmed AA et al.

Allergologia Et Immunopathologia, 0

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