Varaico: Literature-Extracted Genetic Variants

Gene:PIK3CA
Variant:p.M858R
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PIK3CA

NM_006218.4:p.M858R

Associated Papers

Mutational landscape of lung adenocarcinoma in Czechia.

Ambrozkiewicz F et al.

Cancer Treatment and Research Communications, 2026

DNA damage response and repair gene mutations predict clinical outcomes in biliary tract cancer.

Tan S et al.

Cancer, 2025

39876053 (PubMed )
Supplement: supplement_1.pdf

Lung adenocarcinoma with EGFR L858R-K860I and L858R-L861F doublet mutations from which the L858R mutation is undetectable through the cobas EGFR mutation test v2.

Wu CH et al.

Pathology, Research and Practice, 2024

Case report: olaparib use in metastatic lung adenocarcinoma with BRCA2 pathogenic variant.

Soon Jian Hao J et al.

Cold Spring Harbor Molecular Case Studies, 2022

36577523 (PubMed )
Supplement: supp_mcs.a006223_Supplemental_Material.pdf

PIK3CA mutations associated with a poor postoperative prognosis in patients with pulmonary pleomorphic carcinoma: a retrospective cohort study.

Kojima K et al.

Bmc Cancer, 2022

36243681 (PubMed )
Supplement: 12885_2022_10176_MOESM1_ESM.xlsx › Sheet1

Evaluation of the Mutation Profile via Next-Generation Sequencing in a Turkish Population With Non-small Cell Lung Cancer.

Kahraman Çetin N et al.

Balkan Medical Journal, 2021

Oncogenic driver mutations in Swiss never smoker patients with lung adenocarcinoma and correlation with clinicopathologic characteristics and outcome.

Grosse C et al.

Plos One, 2019

Next‑generation sequencing‑based detection of EGFR, KRAS, BRAF, NRAS, PIK3CA, Her‑2 and TP53 mutations in patients with non‑small cell lung cancer.

Jing C et al.

Molecular Medicine Reports, 2018

Clinical mutational profiling of 1006 lung cancers by next generation sequencing.

Illei PB et al.

Oncotarget, 2017

29228562 (PubMed )
Supplement: oncotarget-08-96684-s002.docx

Comparison of plasma to tissue DNA mutations in surgical patients with non-small cell lung cancer.

Chen K et al.

The Journal of Thoracic and Cardiovascular Surgery, 2017

Heterogeneity of resistance mutations detectable by nextgeneration sequencing in TKI-treated lung adenocarcinoma.

Belchis DA et al.

Oncotarget, 2016

27304188 (PubMed )
Supplement: oncotarget-07-45237-s001.pdf

Rapid targeted somatic mutation analysis of solid tumors in routine clinical diagnostics.

Magliacane G et al.

Oncotarget, 2015

Determining lower limits of detection of digital PCR assays for cancer-related gene mutations.

Milbury CA et al.

Biomolecular Detection and Quantification, 2014

Molecular profiling of small cell lung cancer in a Japanese cohort.

Wakuda K et al.

Lung Cancer (amsterdam, Netherlands), 2014

EGFR and KRAS mutational profiling in fresh non-small cell lung cancer (NSCLC) cells.

Stella GM et al.

Journal of Cancer Research and Clinical Oncology, 2013

Molecular pathology of lung cancer: key to personalized medicine.

Cheng L et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2012

Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR.

van Eijk R et al.

Plos One, 2011

A brief retrospective report on the feasibility of epidermal growth factor receptor and KRAS mutation analysis in transesophageal ultrasound- and endobronchial ultrasound-guided fine needle cytological aspirates.

Schuurbiers OC et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2010

Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.

Marks JL et al.

Plos One, 2007

17487277 (PubMed )
Supplement: pone.0000426.s004.doc

Gefitinib-sensitive mutations of the epidermal growth factor receptor tyrosine kinase domain in chinese patients with non-small cell lung cancer.

Mu XL et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."