Varaico: Literature-Extracted Genetic Variants

Gene:PIK3CA
Variant:p.Q859K
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PIK3CA

NM_006218.4:p.Q859K

Associated Papers

The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer.

Cutano V et al.

Npj Breast Cancer, 2025

Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations.

Varkaris A et al.

Cancer Discovery, 2024

Precision Targeting of Mutant PI3Kα.

Gong GQ et al.

Cancer Discovery, 2024

Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110α inhibition.

Zheng Z et al.

Molecular Pharmacology, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."