Varaico: Literature-Extracted Genetic Variants

Gene:PIK3CA
Variant:p.D915N
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PIK3CA

NM_006218.4:p.D915N

Associated Papers

Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis.

Matsubayashi HT et al.

Nature Communications, 2024

Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus.

Jenkins ML et al.

Nature Communications, 2023

Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non-Small Cell Lung Cancer.

Aggarwal C et al.

Jama Oncology, 2019

Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases.

Hon WC et al.

Oncogene, 2012

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."