Associated Papers
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain.
Harris NJ et al.
Elife, 2023
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain.
Harris NJ et al.
Biorxiv : the Preprint Server for Biology, 2023
The role of PI3Kγ in the immune system: new insights and translational implications.
Lanahan SM et al.
Nature Reviews. Immunology, 2022
Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation.
Rathinaswamy MK et al.
Science Advances, 2021
Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors.
Rathinaswamy MK et al.
Elife, 2021
Autoimmunity and immunodeficiency.
Hoyos-Bachiloglu R et al.
Current Opinion in Rheumatology, 2020
Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology.
Takeda AJ et al.
Nature Communications, 2019
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