Varaico: Literature-Extracted Genetic Variants

Gene:PIK3R1
Variant:p.K379E
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PIK3R1

NM_181523.3:p.K379E

Associated Papers

Cancer-Associated PIK3R1 Genetic Aberrations and Precision Medicine.

Xie H et al.

International Journal of Medical Sciences, 2025

Molecular Basis of Oncogenic PI3K Proteins.

Sheng Z et al.

Cancers, 2024

Glioma genetic profiles associated with electrophysiologic hyperexcitability.

Tobochnik S et al.

Neuro-oncology, 2024

Clinical Application of Comprehensive Genomic Profiling Tests for Diffuse Gliomas.

Omura T et al.

Cancers, 2022

35626060 (PubMed )
Supplement: cancers-14-02454-s001.zip › cancers-1674301-SI.xlsx › VUS

Cancer-associated mutations in the p85α N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases.

Li X et al.

Proceedings of the National Academy of Sciences of the United States of America, 2021

Genetic alterations and their therapeutic implications in epithelial ovarian cancer.

Lapke N et al.

Bmc Cancer, 2021

33947352 (PubMed )
Supplement: 12885_2021_8233_MOESM5_ESM.xlsx › Additional_file_5

Intracellular pH dynamics and charge-changing somatic mutations in cancer.

White KA et al.

Cancer Metastasis Reviews, 2019

Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches.

Ellis HP et al.

Journal of Oncology, 2019

32082376 (PubMed )
Supplement: 4878547.f1.zip › 4878547.f1 › Ellis_et_al_SNVs_041018_Supplementary_Tables.xlsx › TableS7_TCGA_mutatons

Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients.

Chen L et al.

Nature Communications, 2018

Insights into the pathological mechanisms of p85α mutations using a yeast-based phosphatidylinositol 3-kinase model.

Oliver MD et al.

Bioscience Reports, 2017

The structural basis of PI3K cancer mutations: from mechanism to therapy.

Liu S et al.

Cancer Research, 2014

Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.

Mellor P et al.

The Biochemical Journal, 2012

Phosphatidylinositol 3-kinase: the oncoprotein.

Vogt PK et al.

Current Topics in Microbiology and Immunology, 2010

Molecular profiling-based decision for targeted therapies in IDH wild-type glioblastoma.

Kessler T et al.

Neuro-oncology Advances, 0

32642725 (PubMed )
Supplement: vdz060_suppl_supplementary-table-s3.xlsx › Sheet1
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."