Varaico: Literature-Extracted Genetic Variants

Gene:PIK3R1
Variant:p.E439del1
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PIK3R1

NM_181523.3:p.E439del1

Associated Papers

Unveiling the role of PIK3R1 in cancer: A comprehensive review of regulatory signaling and therapeutic implications.

Gupta I et al.

Seminars in Cancer Biology, 2024

A novel mutant PIK3R1EY451delinsD breast cancer patient resistant to HER2-targeted therapy treated with everolimus: a case report.

Wang K et al.

Molecular Biology Reports, 2022

PIK3CA gene mutations in the helical domain correlate with high tumor mutation burden and poor prognosis in metastatic breast carcinomas with late-line therapies.

Tang Y et al.

Aging, 2020

Neomorphic mutations create therapeutic challenges in cancer.

Takiar V et al.

Oncogene, 2017

Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

MacConaill LE et al.

The Journal of Molecular Diagnostics : Jmd, 2014

Somatic mutations of PIK3R1 promote gliomagenesis.

Quayle SN et al.

Plos One, 2012

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.

Cheung LW et al.

Cancer Discovery, 2011

Comprehensive genomic characterization defines human glioblastoma genes and core pathways.

Unknown Author

Nature, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."