Associated Papers
An update on the monogenic causes of Parkinson's disease: Impact on patient stratification and personalised medicine.
Asmi S et al.
Ageing Research Reviews, 2026
Cis or trans: a puzzle of Parkin activation mechanism.
Sherawat M et al.
Essays in Biochemistry, 2026
Targeting mitophagy in neurodegenerative diseases.
Antico O et al.
Nature Reviews. Drug Discovery, 2025
Activation of parkin by a molecular glue.
Sauvé V et al.
Nature Communications, 2024
In search for mitochondrial biomarkers of Parkinson's disease: Findings in parkin-mutant human fibroblasts.
Kamienieva I et al.
Biochimica Et Biophysica Acta. Molecular Basis of Disease, 2023
Structure of the second phosphoubiquitin-binding site in parkin.
Fakih R et al.
The Journal of Biological Chemistry, 2022
Animal Models of Autosomal Recessive Parkinsonism.
Bastioli G et al.
Biomedicines, 2021
Multitasking guardian of mitochondrial quality: Parkin function and Parkinson's disease.
Kamienieva I et al.
Translational Neurodegeneration, 2021
Mechanisms of PINK1, ubiquitin and Parkin interactions in mitochondrial quality control and beyond.
Bayne AN et al.
Cellular and Molecular Life Sciences : Cmls, 2019
The landscape of Parkin variants reveals pathogenic mechanisms and therapeutic targets in Parkinson's disease.
Yi W et al.
Human Molecular Genetics, 2019
Genotype-Phenotype Relations for the Parkinson's Disease Genes Parkin, PINK1, DJ1: MDSGene Systematic Review.
Kasten M et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2018
Impact of altered phosphorylation on loss of function of juvenile Parkinsonism-associated genetic variants of the E3 ligase parkin.
Aguirre JD et al.
The Journal of Biological Chemistry, 2018
PINK1 and Parkin: emerging themes in mitochondrial homeostasis.
McWilliams TG et al.
Current Opinion in Cell Biology, 2017
Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation.
Tang MY et al.
Nature Communications, 2017
Dual Function of Phosphoubiquitin in E3 Activation of Parkin.
Walinda E et al.
The Journal of Biological Chemistry, 2016
The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations.
Gautier CA et al.
Human Molecular Genetics, 2016
Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-β hydroxysteroid dehydrogenase type 10.
Bertolin G et al.
Cell Death and Differentiation, 2015
Structural studies of parkin and sacsin: Mitochondrial dynamics in neurodegenerative diseases.
Li X et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2015
Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.
Kazlauskaite A et al.
Open Biology, 2014
The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.
Bertolin G et al.
Autophagy, 2013
[Role of mitophagy in hereditary Parkinson's disease].
Matsuda N et al.
Brain and Nerve = Shinkei Kenkyu No Shinpo, 2012
Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin.
Lazarou M et al.
Developmental Cell, 2012
Dysfunction of mitochondrial respiratory chain complex I in neurological disorders: genetics and pathogenetic mechanisms.
Petruzzella V et al.
Advances in Experimental Medicine and Biology, 2012
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy.
Shiba-Fukushima K et al.
Scientific Reports, 2012
PRKN, DJ-1, and PINK1 screening identifies novel splice site mutation in PRKN and two novel DJ-1 mutations.
Ghazavi F et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2011
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
Matsuda N et al.
The Journal of Cell Biology, 2010
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1.
Geisler S et al.
Nature Cell Biology, 2010
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.
Narendra DP et al.
Plos Biology, 2010
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling.
Sha D et al.
Human Molecular Genetics, 2010
In vitro and in silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5' splice sites.
Sahashi K et al.
Nucleic Acids Research, 2007
Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.
Hampe C et al.
Human Molecular Genetics, 2006
Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.
Sriram SR et al.
Human Molecular Genetics, 2005
Novel parkin mutations detected in patients with early-onset Parkinson's disease.
Bertoli-Avella AM et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2005
Molecular pathways to neurodegeneration.
Bossy-Wetzel E et al.
Nature Medicine, 2004