Associated Papers
An update on the monogenic causes of Parkinson's disease: Impact on patient stratification and personalised medicine.
Asmi S et al.
Ageing Research Reviews, 2026
Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders.
Lu J et al.
Autophagy, 2026
Large-scale genetic characterization of Parkinson's disease in the African and African admixed populations.
Akçimen F et al.
Brain : a Journal of Neurology, 2025
Targeting mitophagy in neurodegenerative diseases.
Antico O et al.
Nature Reviews. Drug Discovery, 2025
Rethinking 'rare' PINK1 Parkinson's disease: A meta-analysis of geographical prevalence, phenotypic diversity, and α-synuclein pathology.
Yin EP et al.
Journal of Parkinson's Disease, 2025
Clinico-Genetic Profiles of Seven Patients With PINK1-Related Parkinson's Disease: A Case Series From a Tertiary Care Centre in India and a Review of the Literature.
Gunasekaran A et al.
Journal of Movement Disorders, 2024
Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson's disease study.
Westenberger A et al.
Brain : a Journal of Neurology, 2024
A molecular simulation study of the clinical G409V mutant in PINK1 associated with early-onset Parkinson's disease.
Lo HH et al.
International Journal of Biological Macromolecules, 2024
Genetics of Parkinson's Disease: state-of-the-art and role in clinical settings.
Dulski J et al.
Neurologia I Neurochirurgia Polska, 2024
Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson's disease.
Trinh J et al.
Brain : a Journal of Neurology, 2023
Structural Mechanisms of Mitochondrial Quality Control Mediated by PINK1 and Parkin.
Trempe JF et al.
Journal of Molecular Biology, 2023
Substitution of PINK1 Gly411 modulates substrate receptivity and turnover.
Fiesel FC et al.
Autophagy, 2023
The Role of Rab Proteins in Mitophagy: Insights into Neurodegenerative Diseases.
Shafique A et al.
International Journal of Molecular Sciences, 2023
Genetic landscape of Parkinson's disease and related diseases in Luxembourg.
Landoulsi Z et al.
Frontiers in Aging Neuroscience, 2023
Human Induced Pluripotent Stem Cell Phenotyping and Preclinical Modeling of Familial Parkinson's Disease.
Kim J et al.
Genes, 2022
Role of Lysosomal Gene Variants in Modulating GBA-Associated Parkinson's Disease Risk.
Straniero L et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2022
PARKIN, PINK1, and DJ1 analysis in early-onset Parkinson's disease in Ireland.
Olszewska DA et al.
Irish Journal of Medical Science, 2022
Monogenic Parkinson's Disease: Genotype, Phenotype, Pathophysiology, and Genetic Testing.
Jia F et al.
Genes, 2022
Parkin beyond Parkinson's Disease-A Functional Meaning of Parkin Downregulation in TDP-43 Proteinopathies.
Gaweda-Walerych K et al.
Cells, 2021
Mitophagy mechanisms in neuronal physiology and pathology during ageing.
Markaki M et al.
Biophysical Reviews, 2021
Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson's Disease.
Vizziello M et al.
Cells, 2021
Modelling Parkinson's Disease: iPSCs towards Better Understanding of Human Pathology.
Avazzadeh S et al.
Brain Sciences, 2021
Community-based genetic study of Parkinson's disease in Estonia.
Muldmaa M et al.
Acta Neurologica Scandinavica, 2021
Genetics of Parkinson's disease in the Polish population.
Milanowski ŁM et al.
Neurologia I Neurochirurgia Polska, 2021
PARK Genes Link Mitochondrial Dysfunction and Alpha-Synuclein Pathology in Sporadic Parkinson's Disease.
Li W et al.
Frontiers in Cell and Developmental Biology, 2021
AsCRISPR: A Web Server for Allele-Specific Single Guide RNA Design in Precision Medicine.
Zhao G et al.
The Crispr Journal, 2020
The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals.
Cao Y et al.
Cell Research, 2020
Comprehensive assessment of PINK1 variants in Parkinson's disease.
Krohn L et al.
Neurobiology of Aging, 2020
Deep brain stimulation for monogenic Parkinson's disease: a systematic review.
Kuusimäki T et al.
Journal of Neurology, 2020
Organoid and pluripotent stem cells in Parkinson's disease modeling: an expert view on their value to drug discovery.
Marotta N et al.
Expert Opinion on Drug Discovery, 2020
Juvenile parkinsonism: Differential diagnosis, genetics, and treatment.
Niemann N et al.
Parkinsonism & Related Disorders, 2019
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.
Yamazaki Y et al.
Nature Reviews. Neurology, 2019
The role of monogenic genes in idiopathic Parkinson's disease.
Reed X et al.
Neurobiology of Disease, 2019
PINK1 autophosphorylation is required for ubiquitin recognition.
Rasool S et al.
Embo Reports, 2018
Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers.
Pritchard AL et al.
Plos One, 2018
Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease.
Zeng XS et al.
Frontiers in Aging Neuroscience, 2018
Structure of PINK1 in complex with its substrate ubiquitin.
Schubert AF et al.
Nature, 2017
Twenty years since the discovery of the parkin gene.
Hattori N et al.
Journal of Neural Transmission (vienna, Austria : 1996), 2017
New Genes Causing Hereditary Parkinson's Disease or Parkinsonism.
Puschmann A
Current Neurology and Neuroscience Reports, 2017
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.
Ando M et al.
Molecular Neurodegeneration, 2017
Ubiquitin and Parkinson's disease through the looking glass of genetics.
Walden H et al.
The Biochemical Journal, 2017
Integrated genomic analyses of de novo pathways underlying atypical meningiomas.
Harmancı AS et al.
Nature Communications, 2017
Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism.
Puschmann A et al.
Brain : a Journal of Neurology, 2017