Associated Papers
An update on the monogenic causes of Parkinson's disease: Impact on patient stratification and personalised medicine.
Asmi S et al.
Ageing Research Reviews, 2026
Type-Specific Single-Neuron Analysis Reveals Mitochondrial DNA Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes.
Stephenson EJ et al.
Aging Cell, 2025
Population-Specific Differences in Pathogenic Variants of Genes Associated with Monogenic Parkinson's Disease.
Flores-Ocampo V et al.
Genes, 2025
Rethinking 'rare' PINK1 Parkinson's disease: A meta-analysis of geographical prevalence, phenotypic diversity, and α-synuclein pathology.
Yin EP et al.
Journal of Parkinson's Disease, 2025
Clinico-Genetic Profiles of Seven Patients With PINK1-Related Parkinson's Disease: A Case Series From a Tertiary Care Centre in India and a Review of the Literature.
Gunasekaran A et al.
Journal of Movement Disorders, 2024
A Novel PINK1 p.F385S Loss-of-Function Mutation in an Indian Family with Parkinson's Disease.
Sharma K et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2024
Exploring the interplay between metabolomics and genetics in Parkinson's disease: Insights from ongoing research and future avenues.
Santos-Rebouças CB et al.
Mechanisms of Ageing and Development, 2023
Is there a special relationship between complex I activity and nigral neuronal loss in Parkinson's disease? A critical reappraisal.
Subrahmanian N et al.
Brain Research, 2021
Identification of sixteen novel candidate genes for late onset Parkinson's disease.
Gialluisi A et al.
Molecular Neurodegeneration, 2021
Nonsense suppression therapies in human genetic diseases.
Martins-Dias P et al.
Cellular and Molecular Life Sciences : Cmls, 2021
PINK1: A Bridge between Mitochondria and Parkinson's Disease.
Gonçalves FB et al.
Life (basel, Switzerland), 2021
Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors.
Bus C et al.
Iscience, 2020
Genetic perspective on the synergistic connection between vesicular transport, lysosomal and mitochondrial pathways associated with Parkinson's disease pathogenesis.
Smolders S et al.
Acta Neuropathologica Communications, 2020
Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases.
Qi Z et al.
Journal of Cellular Physiology, 2019
Pink1 Regulates Tyrosine Hydroxylase Expression and Dopamine Synthesis.
Lu L et al.
Journal of Alzheimer's Disease : Jad, 2018
Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy.
Zhang Y et al.
Cell Chemical Biology, 2017
PINK1 and Parkin: emerging themes in mitochondrial homeostasis.
McWilliams TG et al.
Current Opinion in Cell Biology, 2017
Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy.
Wettengel J et al.
Nucleic Acids Research, 2017
Emerging (and converging) pathways in Parkinson's disease: keeping mitochondrial wellness.
Cieri D et al.
Biochemical and Biophysical Research Communications, 2017
Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism.
Puschmann A et al.
Brain : a Journal of Neurology, 2017
PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?
Truban D et al.
Journal of Parkinson's Disease, 2017
Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance.
Hernandez DG et al.
Journal of Neurochemistry, 2016
Non-motor symptoms and cardiac innervation in SYNJ1-related parkinsonism.
De Rosa A et al.
Parkinsonism & Related Disorders, 2016
Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatment.
Chin LS et al.
Translational Neurodegeneration, 2016
Differential submitochondrial localization of PINK1 as a molecular switch for mediating distinct mitochondrial signaling pathways.
Fallaize D et al.
Cellular Signalling, 2015
Parkinson's disease-associated PINK1 G309D mutation increases abnormal phosphorylation of Tau.
Ye M et al.
Iubmb Life, 2015
Mitochondrial homeostasis molecules: regulation by a trio of recessive Parkinson's disease genes.
Han JY et al.
Experimental Neurobiology, 2014
Detailed analysis of mitochondrial respiratory chain defects caused by loss of PINK1.
Amo T et al.
Neuroscience Letters, 2014
Iron in neurodegenerative disorders of protein misfolding: a case of prion disorders and Parkinson's disease.
Singh N et al.
Antioxidants & Redox Signaling, 2014
PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.
Morais VA et al.
Science (new York, N.y.), 2014
Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons.
Zhou ZD et al.
Free Radical Biology & Medicine, 2014
The Parkinson's disease-associated gene PINK1 protects neurons from ischemic damage by decreasing mitochondrial translocation of the fission promoter Drp1.
Zhao Y et al.
Journal of Neurochemistry, 2013
Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset Parkinsonism.
Quadri M et al.
Human Mutation, 2013
SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria.
Murata H et al.
Molecular Biology of the Cell, 2013
Advances in the genetics of Parkinson disease.
Trinh J et al.
Nature Reviews. Neurology, 2013
PINK1 parkinsonism and Parkinson disease: distinguishable brain mitochondrial function and metabolomics.
Rango M et al.
Mitochondrion, 2013
Parkinson's disease: from genetics to treatments.
Fan HC et al.
Cell Transplantation, 2013
Mutation analysis of the PINK1 gene in Southern Italian patients with early- and late-onset parkinsonism.
Scornaienchi V et al.
Parkinsonism & Related Disorders, 2012
Mitochondrial dynamics and Parkinson's disease: focus on parkin.
Lim KL et al.
Antioxidants & Redox Signaling, 2012
Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness.
Taddei ML et al.
Journal of Signal Transduction, 2012
Dysfunction of mitochondrial respiratory chain complex I in neurological disorders: genetics and pathogenetic mechanisms.
Petruzzella V et al.
Advances in Experimental Medicine and Biology, 2012
Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.
Woodroof HI et al.
Open Biology, 2011
Parkinson disease: insights in clinical, genetic and pathological features of monogenic disease subtypes.
Crosiers D et al.
Journal of Chemical Neuroanatomy, 2011
What genetics tells us about the causes and mechanisms of Parkinson's disease.
Corti O et al.
Physiological Reviews, 2011