Associated Papers
A heteromeric TRP channel that functions as a WNT-activated G protein-coupled receptor.
Hardy EP et al.
Nature Communications, 2026
Hyperosmotic stimuli activate polycystin proteins to aid in urine concentration.
Márquez-Nogueras KM et al.
Jci Insight, 2025
Physiologic mechanisms underlying polycystic kidney disease.
Boletta A et al.
Physiological Reviews, 2025
Cholesterol ensures ciliary polycystin-2 localization to prevent polycystic kidney disease.
Itabashi T et al.
Life Science Alliance, 2025
Identified eleven exon variants in PKD1 and PKD2 genes that altered RNA splicing by minigene assay.
Liu X et al.
Bmc Genomics, 2023
The diverse effects of pathogenic point mutations on ion channel activity of a gain-of-function polycystin-2.
Wang Y et al.
The Journal of Biological Chemistry, 2023
Establishment of transgenic pigs overexpressing human PKD2-D511V mutant.
Zhang Y et al.
Frontiers in Genetics, 2022
Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population.
Walsh S et al.
Scientific Reports, 2020
Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway.
Gerakopoulos V et al.
Life Science Alliance, 2020
Polycystins as components of large multiprotein complexes of polycystin interactors.
Hardy E et al.
Cellular Signalling, 2020
Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain.
Vien TN et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020
Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKD.
Brill AL et al.
Cellular Signalling, 2020
Structure and function of polycystins: insights into polycystic kidney disease.
Douguet D et al.
Nature Reviews. Nephrology, 2019
A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD.
Parnell SC et al.
Human Molecular Genetics, 2018
Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.
Zheng W et al.
Nature Communications, 2018
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Grieben M et al.
Nature Structural & Molecular Biology, 2017
Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2.
Wilkes M et al.
Nature Structural & Molecular Biology, 2017
The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.
Shen PS et al.
Cell, 2016
The polycystin complex mediates Wnt/Ca(2+) signalling.
Kim S et al.
Nature Cell Biology, 2016
Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant.
Arif Pavel M et al.
Proceedings of the National Academy of Sciences of the United States of America, 2016
Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition.
Hofherr A et al.
Kidney International, 2016
Three exonic mutations in polycystic kidney disease-2 gene (PKD2) alter splicing of its pre-mRNA in a minigene system.
Gonzalez-Paredes FJ et al.
Gene, 2016
The functions of TRPP2 in the vascular system.
Du J et al.
Acta Pharmacologica Sinica, 2016
Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS site.
Su X et al.
Journal of Cell Science, 2015
Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.
Gainullin VG et al.
The Journal of Clinical Investigation, 2015
N-glycosylation determines the abundance of the transient receptor potential channel TRPP2.
Hofherr A et al.
The Journal of Biological Chemistry, 2014
Polycystin-2 induces a conformational change in polycystin-1.
Oatley P et al.
Biochemistry, 2013
Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.
Streets AJ et al.
Human Molecular Genetics, 2013
Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells.
Zheleznova NN et al.
Biochimica Et Biophysica Acta, 2011
Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases.
Choi YH et al.
Proceedings of the National Academy of Sciences of the United States of America, 2011
A single amino acid residue constitutes the third dimerization domain essential for the assembly and function of the tetrameric polycystin-2 (TRPP2) channel.
Feng S et al.
The Journal of Biological Chemistry, 2011
Transient receptor potential genes and human inherited disease.
Everett KV
Advances in Experimental Medicine and Biology, 2011
The cell biology of polycystic kidney disease.
Chapin HC et al.
The Journal of Cell Biology, 2010
A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes.
Giamarchi A et al.
The Embo Journal, 2010
Polycystin-1 C-terminal cleavage is modulated by polycystin-2 expression.
Bertuccio CA et al.
The Journal of Biological Chemistry, 2009
Function and regulation of TRPP2 at the plasma membrane.
Tsiokas L
American Journal of Physiology. Renal Physiology, 2009
Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2.
Feng S et al.
The Journal of Biological Chemistry, 2008
Co-inheritance of a PKD1 mutation and homozygous PKD2 variant: a potential modifier in autosomal dominant polycystic kidney disease.
Dedoussis GV et al.
European Journal of Clinical Investigation, 2008
TRPP2 and autosomal dominant polycystic kidney disease.
Köttgen M
Biochimica Et Biophysica Acta, 2007
Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif.
Geng L et al.
Journal of Cell Science, 2006
Polycystin-2 regulates proliferation and branching morphogenesis in kidney epithelial cells.
Grimm DH et al.
The Journal of Biological Chemistry, 2006
Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling.
Li Y et al.
The Journal of Biological Chemistry, 2005
PKD2 functions as an epidermal growth factor-activated plasma membrane channel.
Ma R et al.
Molecular and Cellular Biology, 2005