Associated Papers
Bioinformatics analysis of PSAT1 loss identifies downstream pathways regulated in EGFR mutant NSCLC and a selective gene signature for predicting the risk of relapse.
Biyik-Sit R et al.
Oncology Letters, 2025
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.
Wu Y et al.
Nature Communications, 2023
Identification of residues involved in allosteric signal transmission from amino acid binding site of pyruvate kinase muscle isoform 2.
Nandi S et al.
Plos One, 2023
Nuclear Pyruvate Kinase M2 (PKM2) Contributes to Phosphoserine Aminotransferase 1 (PSAT1)-Mediated Cell Migration in EGFR-Activated Lung Cancer Cells.
Biyik-Sit R et al.
Cancers, 2021
Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation.
Nandi S et al.
The Journal of Biological Chemistry, 2020
Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation.
Chen TJ et al.
Communications Biology, 2019
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