Associated Papers
Nuclear PKM2: a signal receiver, a gene programmer, and a metabolic modulator.
Chen TJ et al.
Journal of Biomedical Science, 2025
Impact of Cancer-Associated PKM2 Mutations on Enzyme Activity and Allosteric Regulation: Structural and Functional Insights into Metabolic Reprogramming.
Upadhyay S et al.
Biochemistry, 2025
Probing altered enzyme activity in the biochemical characterization of cancer.
Adam MAA et al.
Bioscience Reports, 2022
Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity.
Liu VM et al.
Febs Letters, 2020
Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation.
Chen TJ et al.
Communications Biology, 2019
Structural Investigation of a Dimeric Variant of Pyruvate Kinase Muscle Isoform 2.
Srivastava D et al.
Biochemistry, 2017
Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5'-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form.
Yan M et al.
Biochemistry, 2016
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