Associated Papers
Impact of Cancer-Associated PKM2 Mutations on Enzyme Activity and Allosteric Regulation: Structural and Functional Insights into Metabolic Reprogramming.
Upadhyay S et al.
Biochemistry, 2025
40080100 (PubMed )
Supplement: bi5c00009_si_001.pdf
Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin.
Hossain AJ et al.
International Journal of Molecular Sciences, 2023
PKM2 promotes pulmonary fibrosis by stabilizing TGF-β1 receptor I and enhancing TGF-β1 signaling.
Gao S et al.
Science Advances, 2022
Pyruvate Facilitates FACT-Mediated γH2AX Loading to Chromatin and Promotes the Radiation Resistance of Glioblastoma.
Wu S et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2022
Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation.
Nandi S et al.
The Journal of Biological Chemistry, 2020
SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth.
Park SH et al.
Cancer Research, 2016
Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90-EGFR association.
Yang YC et al.
Oncogene, 2016
Structural insight into mechanisms for dynamic regulation of PKM2.
Wang P et al.
Protein & Cell, 2015
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