Varaico: Literature-Extracted Genetic Variants

Gene:PLA2G7
Variant:p.V279F
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PLA2G7

NM_005084.4:p.V279F

Associated Papers

The Association of PLA2G7 Gene Polymorphisms with Serum Lp-PLA2 Activity and Lipid Profile in Han Chinese Patients with Coronary Heart Disease.

Wang Y et al.

Pharmacogenomics and Personalized Medicine, 2024

Activated leukocyte cell adhesion molecule/cluster of differentiation 166 rs10933819 (G>A) variant is associated with familial intracranial aneurysms.

Aitkulova A et al.

Biomedical Reports, 2022

35815187 (PubMed )
Supplement: Supplementary_Data.xlsx › 713_shortlisted_variants

Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation.

Gao X et al.

Molecular Cell, 2022

Association Lp-PLA2 Gene Polymorphisms with Coronary Heart Disease.

Ma S et al.

Disease Markers, 2022

Report on effective treatment and genetic predisposition in two children with refractory probable catastrophic antiphospholipid syndrome.

Pongphitcha P et al.

Thrombosis Research, 2021

Relationship Between Gene Polymorphism of Methylenetetrahydrofolate Reductase C677T and Left Ventricular Hypertrophy in Chinese Patients with Chronic Kidney Disease.

Wu X et al.

Laboratory Medicine, 2021

Functional Analysis of RELN S2486G Mutation and its Contribution to Pathogenesis of Ankylosing Spondylitis.

Esmaeilzadeh-Gharehdaghi E et al.

Archives of Iranian Medicine, 2020

Association of the G994T and R92H genotypes of platelet-activating factor acetylhydrolase with risk of preeclampsia in Chinese women.

Zhou M et al.

Pregnancy Hypertension, 2020

Reinterpretation of common pathogenic variants in ClinVar revealed a high proportion of downgrades.

Xiang J et al.

Scientific Reports, 2020

Human Secretary Phospholipase A2 Mutations and Their Clinical Implications.

Khan MI et al.

Journal of Inflammation Research, 2020

PGG.SNV: understanding the evolutionary and medical implications of human single nucleotide variations in diverse populations.

Zhang C et al.

Genome Biology, 2019

31640808 (PubMed )
Supplement: 13059_2019_1838_MOESM4_ESM.xlsx › Sheet1

Increased activity of lipoprotein-associated phospholipase A2 in non-severe asthma.

Kuczia P et al.

Allergology International : Official Journal of the Japanese Society of Allergology, 2019

Optimizing clinical exome design and parallel gene-testing for recessive genetic conditions in preconception carrier screening: Translational research genomic data from 14,125 exomes.

Capalbo A et al.

Plos Genetics, 2019

31589614 (PubMed )
Supplement: pgen.1008409.s001.xlsx › P_LP_Variants

Impact of a non-synonymous Q281R polymorphism on structure of human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2 ).

Gurung AB et al.

Journal of Cellular Biochemistry, 2018

Interaction between nonsynonymous polymorphisms in PLA2G7 gene and smoking on the risk of coronary heart disease in a Chinese population.

Chi Y et al.

Journal of Thrombosis and Thrombolysis, 2018

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.

Rivas MA et al.

Plos Genetics, 2018

29795570 (PubMed )
Supplement: pgen.1007329.s012.xlsx › Data_File_S3

[Association between platelet-activating factor acetylhydrolase gene polymorphisms and gastrointestinal bleeding in children with Henoch-Schönlein purpura].

Wang BX et al.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 2017

Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles.

Gregson JM et al.

European Journal of Preventive Cardiology, 2017

Effects of overweight and the PLA2G7 V279F polymorphism on the association of age with systolic blood pressure.

Kim M et al.

Plos One, 2017

Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib.

Yeo A et al.

Plos One, 2017

Associations between four types of single-nucleotide polymorphisms in PLA2G7 gene and clinical atherosclerosis: a meta-analysis.

Santoso A et al.

American Journal of Cardiovascular Disease, 2017

A previously unreported impact of a PLA2G7 gene polymorphism on the plasma levels of lipoprotein-associated phospholipase A2 activity and mass.

Qi Y et al.

Scientific Reports, 2016

Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction.

Cahyaningtias M et al.

Genes & Diseases, 2016

A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults.

Millwood IY et al.

International Journal of Epidemiology, 2016

Association between Ala379Val polymorphism of lipoprotein-associated phospholipase A2 and migraine without aura in Iranian population.

Haghdoost F et al.

Iranian Journal of Neurology, 2016

Associations of platelet-activating factor acetylhydrolase gene polymorphisms with risk of ischemic stroke.

Ma Y

Biomedical Reports, 2016

Lipoprotein-Associated Phospholipase A2 Loss-of-Function Variant and Risk of Vascular Diseases in 90,000 Chinese Adults.

Millwood IY et al.

Journal of the American College of Cardiology, 2016

Nonsynonymous polymorphisms in PLA2G7 gene are associated with the risk of coronary heart disease in a southern Chinese population.

Hong M et al.

Mammalian Genome : Official Journal of the International Mammalian Genome Society, 2015

Effects of A379V variant of the Lp-PLA 2 gene on Lp-PLA 2 activity and markers of oxidative stress and endothelial function in Koreans.

Chae JS et al.

Journal of Thrombosis and Thrombolysis, 2014

Associations of platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphisms with circulating PAF-AH levels and risk of coronary heart disease or blood stasis syndrome in the Chinese Han population.

Zheng GH et al.

Molecular Biology Reports, 2014

[Association between gene polymorphism of CD40 gene and coronary artery lesion in Kawasaki disease].

Cheng SC et al.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 2014

Association of PLA2G7 gene polymorphisms with ischemic stroke in northern Chinese Han population.

Liu X et al.

Clinical Biochemistry, 2014

The prevalence of platelet activating factor acetylhydrolase single nucleotide polymorphisms in relationship to necrotizing enterocolitis in Northwest Louisiana infants.

Sankararaman S et al.

Springerplus, 2013

An association study between genetic polymorphisms related to lipoprotein-associated phospholipase A(2) and coronary heart disease.

Xu L et al.

Experimental and Therapeutic Medicine, 2013

Effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity in Japanese dyslipidemic patients, with exploratory analysis of a PLA2G7 gene polymorphism of Val279Phe.

Daida H et al.

Circulation Journal : Official Journal of the Japanese Circulation Society, 2013

Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.

Chu AY et al.

Circulation. Cardiovascular Genetics, 2012

Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations.

Song K et al.

The Pharmacogenomics Journal, 2012

[Association between platelet-activating factor acetylhydrolase gene polymorphism and intracranial hemorrhage in preterm infants].

Zhang Q et al.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 2012

Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.

Grallert H et al.

European Heart Journal, 2012

Association between lipoprotein-associated phospholipase A2 gene polymorphism and coronary artery disease in the Chinese Han population.

Li L et al.

Annals of Human Genetics, 2011

Lipoprotein-associated phospholipase A2 gene V279F polymorphisms and coronary heart disease: a meta-analysis.

Zheng GH et al.

Molecular Biology Reports, 2011

Carriage of the V279F null allele within the gene encoding Lp-PLA₂ is protective from coronary artery disease in South Korean males.

Jang Y et al.

Plos One, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."