Varaico: Literature-Extracted Genetic Variants

Gene:PLCG1
Variant:p.R707Q
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PLCG1

NM_002660.3:p.R707Q

Associated Papers

Comparative Analysis of a Dual DNA-RNA Panel and a DNA-Only Panel for Sarcoma: Real-World Data From a Nationwide Genomic Database.

Nakata E et al.

Cancer Science, 2026

41128349 (PubMed )
Supplement: CAS-117-156-s003.xlsx › Sheet1

Genomic landscape and preclinical models of angiosarcoma.

Benton A et al.

Molecular Oncology, 2025

New molecular targets in canine hemangiosarcoma-Comparative review and future of the precision medicine.

Kapturska KM et al.

Veterinary and Comparative Oncology, 2023

Recent advances in understanding the molecular role of phosphoinositide-specific phospholipase C gamma 1 as an emerging onco-driver and novel therapeutic target in human carcinogenesis.

Mandal S et al.

Biochimica Et Biophysica Acta. Reviews on Cancer, 2021

A computational in silico approach to predict high-risk coding and non-coding SNPs of human PLCG1 gene.

Khan SM et al.

Plos One, 2021

Phospholipase C families: Common themes and versatility in physiology and pathology.

Katan M et al.

Progress in Lipid Research, 2020

Dramatic response of metastatic cutaneous angiosarcoma to an immune checkpoint inhibitor in a patient with xeroderma pigmentosum: whole-genome sequencing aids treatment decision in end-stage disease.

Momen S et al.

Cold Spring Harbor Molecular Case Studies, 2019

Identification of different mutational profiles in cancers arising in specific colon segments by next generation sequencing.

Oliveira DM et al.

Oncotarget, 2018

29844865 (PubMed )
Supplement: oncotarget-09-23960-s003.xlsx › Supplemental_Table_S2

Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling.

Wang M et al.

Oncotarget, 2017

Actionable mutations in canine hemangiosarcoma.

Wang G et al.

Plos One, 2017

Recurrent CIC Gene Abnormalities in Angiosarcomas: A Molecular Study of 120 Cases With Concurrent Investigation of PLCG1, KDR, MYC, and FLT4 Gene Alterations.

Huang SC et al.

The American Journal of Surgical Pathology, 2016

The phosphoproteome of human Jurkat T cell clones upon costimulation with anti-CD3/anti-CD28 antibodies.

Nguyen TD et al.

Journal of Proteomics, 2016

Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway.

Murali R et al.

Oncotarget, 2015

Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma.

Prenen H et al.

Oncotarget, 2015

A recurrent activating PLCG1 mutation in cardiac angiosarcomas increases apoptosis resistance and invasiveness of endothelial cells.

Kunze K et al.

Cancer Research, 2014

Recurrent PTPRB and PLCG1 mutations in angiosarcoma.

Behjati S et al.

Nature Genetics, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."