Associated Papers
PLCG2 across human disease: genetic variants, signaling mechanisms, and clinical implications.
Jiang P et al.
Journal of Translational Medicine, 2026
Alzheimer's disease-associated PLCG2 variants alter microglial state and function in human induced pluripotent stem cell-derived microglia-like cells.
Bedford LM et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2025
PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology.
Messenger EJ et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2025
The crystal and cryo-EM structures of PLCγ2 reveal dynamic interdomain recognitions in autoinhibition.
Shin YC et al.
Science Advances, 2024
In vivo validation of late-onset Alzheimer's disease genetic risk factors.
Sasner M et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2024
The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function - Insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation.
Bull D et al.
Biochimica Et Biophysica Acta. Molecular Basis of Disease, 2024
In vivo validation of late-onset Alzheimer's disease genetic risk factors.
Sasner M et al.
Biorxiv : the Preprint Server for Biology, 2023
Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain.
Hopp SC et al.
Biorxiv : the Preprint Server for Biology, 2023
Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.
Tsai AP et al.
Immunity, 2023
Carriers of the p.P522R variant in PLCγ2 have a slightly more responsive immune system.
Diks AM et al.
Molecular Neurodegeneration, 2023
Immunogenetics associated with severe coccidioidomycosis.
Hsu AP et al.
Jci Insight, 2022
Identification of variants in genes associated with autoinflammatory disorders in a cohort of patients with psoriatic arthritis.
Atschekzei F et al.
Rmd Open, 2022
Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer's Disease-Relevant Phenotypes in Mice.
Oblak AL et al.
Frontiers in Aging Neuroscience, 2022
Dementia-related genetic variants in an Italian population of early-onset Alzheimer's disease.
Bartoletti-Stella A et al.
Frontiers in Aging Neuroscience, 2022
PLCγ2 impacts microglia-related effectors revealing variants and pathways important in Alzheimer's disease.
Li K et al.
Frontiers in Cell and Developmental Biology, 2022
The impact of rare and low-frequency genetic variants in common variable immunodeficiency (CVID).
Bisgin A et al.
Scientific Reports, 2021
Genome sequencing unveils mutational landscape of the familial Mediterranean fever: Potential implications of IL33/ST2 signalling.
Umar M et al.
Journal of Cellular and Molecular Medicine, 2020
Development and Validation of a Targeted Next-Generation Sequencing Gene Panel for Children With Neuroinflammation.
McCreary D et al.
Jama Network Open, 2019
The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein.
Walliser C et al.
The Journal of Biological Chemistry, 2016
Lysoplex: An efficient toolkit to detect DNA sequence variations in the autophagy-lysosomal pathway.
Di Fruscio G et al.
Autophagy, 2015