Varaico: Literature-Extracted Genetic Variants

Gene:PLCG2
Variant:p.R742P
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PLCG2

NM_002661.5:p.R742P

Associated Papers

PLCG2 across human disease: genetic variants, signaling mechanisms, and clinical implications.

Jiang P et al.

Journal of Translational Medicine, 2026

Absence of BTK, BCL2, and PLCG2 Mutations in Chronic Lymphocytic Leukemia Relapsing after First-Line Treatment with Fixed-Duration Ibrutinib plus Venetoclax.

Jain N et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

Molecular associations of response to the new-generation BTK inhibitor zanubrutinib in marginal zone lymphoma.

Tatarczuch M et al.

Blood Advances, 2023

Genetic and Non-Genetic Mechanisms of Resistance to BCR Signaling Inhibitors in B Cell Malignancies.

Ondrisova L et al.

Frontiers in Oncology, 2020

33154951 (PubMed )
Supplement: DataSheet_1.pdf

Dissection of subclonal evolution by temporal mutation profiling in chronic lymphocytic leukemia patients treated with ibrutinib.

Gángó A et al.

International Journal of Cancer, 2020

Resistance-Associated Mutations in Chronic Lymphocytic Leukemia Patients Treated With Novel Agents.

Sedlarikova L et al.

Frontiers in Oncology, 2020

Are BTK and PLCG2 mutations necessary and sufficient for ibrutinib resistance in chronic lymphocytic leukemia?

Lampson BL et al.

Expert Review of Hematology, 2018

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."