Associated Papers
Structural Implications of H233L and H398P Mutations in Phospholipase Cζ: A Full-Atom Molecular Dynamics Study on Infertility-Associated Dysfunctions.
Hinostroza F et al.
International Journal of Molecular Sciences, 2025
Novel PLCZ1 compound heterozygous mutations indicate gene dosage effect involved in total fertilisation failure after ICSI.
Li Q et al.
Reproduction (cambridge, England), 2024
High rate of detected variants in male PLCZ1 and ACTL7A genes causing failed fertilization after ICSI.
Cardona Barberán A et al.
Human Reproduction Open, 2024
Exonic genetic variants associated with unexpected fertilization failure and zygotic arrest after ICSI: a systematic review.
Torra-Massana M et al.
Zygote (cambridge, England), 2023
Novel mutations in PLCZ1 lead to early embryonic arrest as a male factor.
Lin Y et al.
Frontiers in Cell and Developmental Biology, 2023
SPERM FACTORS AND EGG ACTIVATION: Phospholipase C zeta (PLCZ1) and the clinical diagnosis of oocyte activation deficiency.
Jones C et al.
Reproduction (cambridge, England), 2022
SPERM FACTORS AND EGG ACTIVATION: The structure and function relationship of sperm PLCZ1.
Thanassoulas A et al.
Reproduction (cambridge, England), 2022
Gene mutations associated with fertilization failure after in vitro fertilization/intracytoplasmic sperm injection.
Xue Y et al.
Frontiers in Endocrinology, 2022
Genetic variations as molecular diagnostic factors for idiopathic male infertility: current knowledge and future perspectives.
Karimian M et al.
Expert Review of Molecular Diagnostics, 2021
A novel homozygous mutation of phospholipase C zeta leading to defective human oocyte activation and fertilization failure.
Yuan P et al.
Human Reproduction (oxford, England), 2020
A homozygous nonsense mutation of PLCZ1 cause male infertility with oocyte activation deficiency.
Wang F et al.
Journal of Assisted Reproduction and Genetics, 2020
The identification of novel mutations in PLCZ1 responsible for human fertilization failure and a therapeutic intervention by artificial oocyte activation.
Mu J et al.
Molecular Human Reproduction, 2020
Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization.
Yan Z et al.
Human Reproduction (oxford, England), 2020
Novel phospholipase C zeta 1 mutations associated with fertilization failures after ICSI.
Torra-Massana M et al.
Human Reproduction (oxford, England), 2019
Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ.
Nomikos M et al.
The Biochemical Journal, 2017
PLCζ sequence, protein levels, and distribution in human sperm do not correlate with semen characteristics and fertilization rates after ICSI.
Ferrer-Vaquer A et al.
Journal of Assisted Reproduction and Genetics, 2016
Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility.
Nomikos M et al.
Fertility and Sterility, 2013
Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells.
Kashir J et al.
Fertility and Sterility, 2012
A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility.
Kashir J et al.
Human Reproduction (oxford, England), 2012