Varaico: Literature-Extracted Genetic Variants

Gene:PLD2
Variant:p.K758R
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PLD2

NM_002663.5:p.K758R

Associated Papers

Super-resolution imaging of potassium channels with genetically encoded EGFP.

Call IM et al.

Biorxiv : the Preprint Server for Biology, 2023

The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson's Disease.

Mendez-Gomez HR et al.

Neuroscience, 2018

PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination.

Kim JD et al.

Science Advances, 2015

26665171 (PubMed )
Supplement: 1500615_SM.pdf

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.

Cruchaga C et al.

Nature, 2014

Attenuated PLD1 association and signalling at the H452Y polymorphic form of the 5-HT(2A) receptor.

Barclay Z et al.

Cellular Signalling, 2013

A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanism.

Kantonen S et al.

Molecular and Cellular Biology, 2011

Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling.

Frondorf K et al.

The Journal of Biological Chemistry, 2010

Phosphatidic acid metabolism regulates the intracellular trafficking and retrotranslocation of CFTR.

Hashimoto Y et al.

Biochimica Et Biophysica Acta, 2008

Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner.

Di Fulvio M et al.

Cellular Signalling, 2008

Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.

Zhao C et al.

Nature Cell Biology, 2007

Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR.

Lehman N et al.

Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2007

Catalytic inactivation of human phospholipase D2 by a naturally occurring Gly901Asp mutation.

Yamada Y et al.

Archives of Medical Research, 2006

Dual role for phosphoinositides in regulation of yeast and mammalian phospholipase D enzymes.

Sciorra VA et al.

The Journal of Cell Biology, 2002

Molecular analysis of mammalian phospholipase D2.

Sung TC et al.

The Journal of Biological Chemistry, 1999

Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity.

Sung TC et al.

The Embo Journal, 1997

Structure analysis between the SWAP-70 RHO-GEF and the newly described PLD2-GEF.

Gomez-Cambronero J

Small Gtpases, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."