Associated Papers
Crystal structure of Alzheimer's disease phospholipase D3 provides a molecular basis for understanding its normal and pathological functions.
Ishii K et al.
The Febs Journal, 2024
Structure of human phospholipase D3, a single-strand exonuclease associated with Alzheimer's disease.
Bijelic A et al.
The Febs Journal, 2024
PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes.
Singh S et al.
Cell, 2024
Phospholipase D3 regulates TFEB/TFE3 metabolism to maintain lysosomal homeostasis.
Wang Y et al.
Biorxiv : the Preprint Server for Biology, 2024
Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation.
Bérouti M et al.
Immunity, 2024
Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4.
Yuan M et al.
Structure (london, England : 1993), 2024
PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes.
Singh S et al.
Biorxiv : the Preprint Server for Biology, 2024
Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4.
Yuan M et al.
Biorxiv : the Preprint Server for Biology, 2023
Neuroprotective factors affect the progression of Alzheimer's disease.
Liu Y et al.
Biochemical and Biophysical Research Communications, 2023
Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism.
Van Acker ZP et al.
Nature Communications, 2023
RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis.
Wong S et al.
Embo Molecular Medicine, 2023
Genetics of Alzheimer's disease: an East Asian perspective.
Miyashita A et al.
Journal of Human Genetics, 2023
Intervention of next-generation sequencing in diagnosis of Alzheimer's disease: challenges and future prospects.
Chandy T
Dementia & Neuropsychologia, 2023
PLD3 affects axonal spheroids and network defects in Alzheimer's disease.
Yuan P et al.
Nature, 2022
Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.
Khang R et al.
Scientific Reports, 2021
The transcriptional landscape of Alzheimer's disease and its association with Wnt signaling pathway.
Martínez M et al.
Neuroscience and Biobehavioral Reviews, 2021
PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease.
Nackenoff AG et al.
Plos Genetics, 2021
Association of rare variants in neurodegenerative genes with familial Alzheimer's disease.
Zhang W et al.
Annals of Clinical and Translational Neurology, 2020
Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles.
Cochran JN et al.
Cold Spring Harbor Molecular Case Studies, 2019
Association of Acquired and Heritable Factors With Intergenerational Differences in Age at Symptomatic Onset of Alzheimer Disease Between Offspring and Parents With Dementia.
Day GS et al.
Jama Network Open, 2019
V232M substitution restricts a distinct O-glycosylation of PLD3 and its neuroprotective function.
Demirev AV et al.
Neurobiology of Disease, 2019
Whole-Exome Sequencing of an Exceptional Longevity Cohort.
Nygaard HB et al.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 2019
A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease.
Zhang X et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2019
Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese.
Zhang DF et al.
National Science Review, 2019
PLD3 Rare Variants Identified in Late-Onset Alzheimer's Disease Affect Amyloid-β Levels in Cellular Model.
Tan M et al.
Frontiers in Neuroscience, 2019
PLD3 epigenetic changes in the hippocampus of Alzheimer's disease.
Blanco-Luquin I et al.
Clinical Epigenetics, 2018
The effect of rare variants in TREM2 and PLD3 on longitudinal cognitive function in the Wisconsin Registry for Alzheimer's Prevention.
Engelman CD et al.
Neurobiology of Aging, 2018
Genome-wide significant risk factors on chromosome 19 and the APOE locus.
Moreno-Grau S et al.
Oncotarget, 2018
Rare Variants in PLD3 Increase Risk for Alzheimer's Disease in Han Chinese.
Tan MS et al.
Journal of Alzheimer's Disease : Jad, 2018
Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience.
Ridge PG et al.
Genome Medicine, 2017
Genetics of Alzheimer's disease: From pathogenesis to clinical usage.
Shao W et al.
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 2017
Genetics of Alzheimer's Disease: the Importance of Polygenic and Epistatic Components.
Raghavan N et al.
Current Neurology and Neuroscience Reports, 2017
Molecular Genetics of Neurodegenerative Dementias.
Hinz FI et al.
Cold Spring Harbor Perspectives in Biology, 2017
State of Play in Alzheimer's Disease Genetics.
Zhu JB et al.
Journal of Alzheimer's Disease : Jad, 2017
Genetic Biomarkers on Age-Related Cognitive Decline.
Lin CH et al.
Frontiers in Psychiatry, 2017
Genomics of Alzheimer's disease: Value of high-throughput genomic technologies to dissect its etiology.
Tosto G et al.
Molecular and Cellular Probes, 2016
Impact of Common Variations in PLD3 on Neuroimaging Phenotypes in Non-demented Elders.
Wang C et al.
Molecular Neurobiology, 2016
PLD3 in Alzheimer's Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses.
Zhang DF et al.
Molecular Neurobiology, 2016
Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians.
Freudenberg-Hua Y et al.
Human Molecular Genetics, 2016
Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond.
Cuyvers E et al.
The Lancet. Neurology, 2016
The genetic landscape of Alzheimer disease: clinical implications and perspectives.
Van Cauwenberghe C et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2016
Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk.
Ebbert MTW et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2016
Rare truncating variations and risk of schizophrenia: Whole-exome sequencing in three families with affected siblings and a three-stage follow-up study in a Japanese population.
Watanabe Y et al.
Psychiatry Research, 2016