Varaico: Literature-Extracted Genetic Variants

Gene:PLK1
Variant:p.K82R
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PLK1

NM_005030.6:p.K82R

Associated Papers

Hornerin mediates phosphorylation of the polo-box domain in Plk1 by Chk1 to induce death in mitosis.

Song H et al.

Cell Death and Differentiation, 2023

The toxicity of dysregulated Plk1 activity revealed by its suppressor mutations.

Kamakura N et al.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2023

UBAP2L-dependent coupling of PLK1 localization and stability during mitosis.

Guerber L et al.

Embo Reports, 2023

37039032 (PubMed )
Supplement: EMBR-24-e56241-s011.pdf

Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry.

Tavernier N et al.

Nature Communications, 2021

A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division.

Owa M et al.

Communications Biology, 2021

33742057 (PubMed )
Supplement: 42003_2021_1861_MOESM5_ESM.xlsx › Supple_figure_4c

Actin-dependent regulation of cilia length by the inverted formin FHDC1.

Copeland SJ et al.

Molecular Biology of the Cell, 2018

Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway.

Ma X et al.

Nature Communications, 2017

The Functional Significance of Posttranslational Modifications on Polo-Like Kinase 1 Revealed by Chemical Genetic Complementation.

Lasek AL et al.

Plos One, 2016

The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores.

Lee HS et al.

Nature Communications, 2015

A unique insertion in STARD9's motor domain regulates its stability.

Senese S et al.

Molecular Biology of the Cell, 2015

BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.

Zou J et al.

Cell Cycle (georgetown, Tex.), 2014

PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition.

Kasahara K et al.

Nature Communications, 2013

FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.

Zou J et al.

Biology Open, 2013

Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation.

Ha GH et al.

Cell Death and Differentiation, 2012

A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1.

Chen YJ et al.

The Journal of Biological Chemistry, 2009

The role of Polo-like kinase 1 in the inhibition of centrosome separation after ionizing radiation.

Zhang W et al.

The Journal of Biological Chemistry, 2005

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.

Elia AE et al.

Cell, 2003

Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.

Casenghi M et al.

Developmental Cell, 2003

Polo-like kinase-1 is a target of the DNA damage checkpoint.

Smits VA et al.

Nature Cell Biology, 2000

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

Golsteyn RM et al.

The Journal of Cell Biology, 1995

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."