Associated Papers
The E3 ligase TRIM26 suppresses ferroptosis through catalyzing K63-linked ubiquitination of GPX4 in glioma.
Wang Z et al.
Cell Death & Disease, 2023
PLK1-ELAVL1/HuR-miR-122 signaling facilitates hepatitis C virus proliferation.
Seo Y et al.
Proceedings of the National Academy of Sciences of the United States of America, 2022
Phosphorylation of β-catenin Ser60 by polo-like kinase 1 drives the completion of cytokinesis.
Yu JE et al.
Embo Reports, 2021
PLK1 targets CtIP to promote microhomology-mediated end joining.
Wang H et al.
Nucleic Acids Research, 2018
Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity.
Kettenbach AN et al.
Science Signaling, 2018
Plk1 phosphorylation of Numb leads to impaired DNA damage response.
Shao C et al.
Oncogene, 2018
Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response.
Li Z et al.
Cancer Research, 2017
Plk1-mediated stabilization of 53BP1 through USP7 regulates centrosome positioning to maintain bipolarity.
Yim H et al.
Oncogene, 2017
Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.
Borgal L et al.
Cell Cycle (georgetown, Tex.), 2016
Mammalian Polo-like kinase 1 (Plk1) promotes proper chromosome segregation by phosphorylating and delocalizing the PBIP1·CENP-Q complex from kinetochores.
Park CH et al.
The Journal of Biological Chemistry, 2015
Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.
Li Z et al.
Molecular and Cellular Biology, 2014
Polo-like kinase 1 regulates the stability of the mitotic centromere-associated kinesin in mitosis.
Sanhaji M et al.
Oncotarget, 2014
In-silico screening of cancer associated mutation on PLK1 protein and its structural consequences.
Kamaraj B et al.
Journal of Molecular Modeling, 2013
NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpoint.
Ando K et al.
Plos One, 2013
Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.
Lee KH et al.
The Embo Journal, 2012
PLK1 interacts and phosphorylates Axin that is essential for proper centrosome formation.
Ruan K et al.
Plos One, 2012
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Yun SM et al.
Nature Structural & Molecular Biology, 2009
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.
Wolfe BA et al.
Plos Biology, 2009
Phospho-regulation of HsCdc14A By Polo-like kinase 1 is essential for mitotic progression.
Yuan K et al.
The Journal of Biological Chemistry, 2007
Ectopic expression of Plk1 leads to activation of the spindle checkpoint.
Tang J et al.
Cell Cycle (georgetown, Tex.), 2006
Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner.
Astrinidis A et al.
Human Molecular Genetics, 2006
The Plk1 Polo box domain mediates a cell cycle and DNA damage regulated interaction with Chk2.
Tsvetkov LM et al.
Cell Cycle (georgetown, Tex.), 2005
B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1.
Zhang H et al.
The Journal of Biological Chemistry, 2004
Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation.
Ando K et al.
The Journal of Biological Chemistry, 2004
M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex.
Lin HR et al.
The Journal of Biological Chemistry, 2003
A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells.
Seong YS et al.
The Journal of Biological Chemistry, 2002