Varaico: Literature-Extracted Genetic Variants

Gene:PLK1
Variant:p.S137A
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PLK1

NM_005030.6:p.S137A

Associated Papers

Hornerin mediates phosphorylation of the polo-box domain in Plk1 by Chk1 to induce death in mitosis.

Song H et al.

Cell Death and Differentiation, 2023

PPP4C facilitates homologous recombination DNA repair by dephosphorylating PLK1 during early embryo development.

Dong MZ et al.

Development (cambridge, England), 2022

PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair.

Peng B et al.

Nucleic Acids Research, 2021

The Functional Significance of Posttranslational Modifications on Polo-Like Kinase 1 Revealed by Chemical Genetic Complementation.

Lasek AL et al.

Plos One, 2016

In-silico screening of cancer associated mutation on PLK1 protein and its structural consequences.

Kamaraj B et al.

Journal of Molecular Modeling, 2013

Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.

van de Weerdt BC et al.

Molecular and Cellular Biology, 2005

Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.

Tsvetkov L et al.

Cell Cycle (georgetown, Tex.), 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."