Varaico: Literature-Extracted Genetic Variants

Gene:PLK4
Variant:p.D154A
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PLK4

NM_014264.5:p.D154A

Associated Papers

PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome.

Yang XD et al.

The Embo Journal, 2020

POLQ Overexpression Is Associated with an Increased Somatic Mutation Load and PLK4 Overexpression in Lung Adenocarcinoma.

Shinmura K et al.

Cancers, 2019

Human male infertility and its genetic causes.

Miyamoto T et al.

Reproductive Medicine and Biology, 2017

KinView: a visual comparative sequence analysis tool for integrated kinome research.

McSkimming DI et al.

Molecular Biosystems, 2016

A PLK4 mutation causing azoospermia in a man with Sertoli cell-only syndrome.

Miyamoto T et al.

Andrology, 2016

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication.

Arquint C et al.

Elife, 2015

[Molecular mechanisms of centriole duplication].

Kitagawa D

Seikagaku. the Journal of Japanese Biochemical Society, 2012

Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels.

Korzeniewski N et al.

Cancer Research, 2009

The Polo kinase Plk4 functions in centriole duplication.

Habedanck R et al.

Nature Cell Biology, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."