Varaico: Literature-Extracted Genetic Variants

Gene:PML
Variant:p.L217F
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PML

NM_033238.3:p.L217F

Associated Papers

Mutations at proximal cysteine residues in PML impair ATO binding by destabilizing the RBCC domain.

Dubey S et al.

The Febs Journal, 2024

Phase separation is required for PML nuclear body biogenesis and function.

Wu W et al.

Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2023

Varying responses of PML-RARA with different genetic mutations to arsenic trioxide.

Liu J et al.

Blood, 2016

Evaluating frequency of PML-RARA mutations and conferring resistance to arsenic trioxide-based therapy in relapsed acute promyelocytic leukemia patients.

Lou Y et al.

Annals of Hematology, 2015

Secondary mutations as mediators of resistance to targeted therapy in leukemia.

Daver N et al.

Blood, 2015

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."