Varaico: Literature-Extracted Genetic Variants

Gene:PML
Variant:p.L218P
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PML

NM_033238.3:p.L218P

Associated Papers

Mutation in the Unrearranged PML Allele Confers Resistance to Arsenic Trioxide in Acute Promyelocytic Leukemia.

Yu PH et al.

Research (washington, D.c.), 2025

Mutations at proximal cysteine residues in PML impair ATO binding by destabilizing the RBCC domain.

Dubey S et al.

The Febs Journal, 2024

Phase separation is required for PML nuclear body biogenesis and function.

Wu W et al.

Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2023

Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Hescheler DA et al.

Frontiers in Endocrinology, 2021

34630336 (PubMed )
Supplement: Table_1.xlsx › Tab2

Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment.

Goto E et al.

Blood, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."