Varaico: Literature-Extracted Genetic Variants

Gene:PML
Variant:p.K490R
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PML

NM_033238.3:p.K490R

Associated Papers

PML targets and resolves structured protein inclusions to mitigate neurodegeneration.

Wang Y et al.

Nature Cell Biology, 2026

Phase separation is required for PML nuclear body biogenesis and function.

Wu W et al.

Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2023

PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus.

Burroughs AF et al.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 2018

An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.

Kuo CY et al.

The Journal of Biological Chemistry, 2014

Dual roles for lysine 490 of promyelocytic leukemia protein in the transactivation of glucocorticoid receptor-interacting protein 1.

Liu ST et al.

Biochimica Et Biophysica Acta, 2013

Identification of three major sentrinization sites in PML.

Kamitani T et al.

The Journal of Biological Chemistry, 1998

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."