Varaico: Literature-Extracted Genetic Variants

Gene:PNP
Variant:p.N243D
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PNP

NM_000270.4:p.N243D

Associated Papers

Computer Simulations Reveal Substrate Specificity of Glycosidic Bond Cleavage in Native and Mutant Human Purine Nucleoside Phosphorylase.

Isaksen GV et al.

Biochemistry, 2016

Unraveling the structural and functional differences between purine nucleoside phosphorylase and 5'-deoxy-5'-methylthioadenosine phosphorylase from the archaeon Pyrococcus furiosus.

Cacciapuoti G et al.

Biochimica Et Biophysica Acta, 2011

Role of Charged Residues in the Catalytic Sites of Escherichia coli ATP Synthase.

Ahmad Z et al.

Journal of Amino Acids, 2011

Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine.

Afshar S et al.

Protein Science : a Publication of the Protein Society, 2009

Design of an adenosine phosphorylase by active-site modification of murine purine nucleoside phosphorylase. Enzyme kinetics and molecular dynamics simulation of Asn-243 and Lys-244 substitutions of purine nucleoside phosphorylase.

Maynes JT et al.

The Biochemical Journal, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."