Varaico: Literature-Extracted Genetic Variants

Gene:PNPLA3
Variant:p.P446L
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PNPLA3

NM_025225.3:p.P446L

Associated Papers

Genetic Variations in GCKR and PNPLA3 Regulate Metabolic Balance Across the Liver.

Ma Y et al.

Diabetes, 2025

Association of GCKR and MBOAT7 genetic polymorphisms with non-alcoholic fatty liver disease.

Chavan SU et al.

Clinical and Experimental Hepatology, 2024

En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH.

Kimura M et al.

Cell, 2022

The association between rs1260326 with the risk of NAFLD and the mediation effect of triglyceride on NAFLD in the elderly Chinese Han population.

Yuan F et al.

Aging, 2022

Sirtuin3 rs28365927 functional variant confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population.

Chen LJ et al.

Lipids in Health and Disease, 2021

Heterozygosity of the Alpha 1-Antitrypsin Pi*Z Allele and Risk of Liver Disease.

Hakim A et al.

Hepatology Communications, 2021

Is HSD17B13 Genetic Variant a Protector for Liver Dysfunction? Future Perspective as a Potential Therapeutic Target.

Motomura T et al.

Journal of Personalized Medicine, 2021

Assessment of Genetic Aspects of Non-alcoholic Fatty Liver and Premature Cardiovascular Events.

Saki S et al.

Middle East Journal of Digestive Diseases, 2020

Insights into paediatric non-alcoholic fatty liver disease from genetic variants.

Dong J et al.

Liver International : Official Journal of the International Association for the Study of the Liver, 2019

Promoting genetics in non-alcoholic fatty liver disease: Combined risk score through polymorphisms and clinical variables.

Vespasiani-Gentilucci U et al.

World Journal of Gastroenterology, 2018

A modified response of NAFLD patients with non-significant fibrosis in nutritional counseling according to GCKR rs1260326.

Kaliora AC et al.

European Journal of Nutrition, 2018

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver.

Dongiovanni P et al.

Journal of Internal Medicine, 2018

29280273 (PubMed )
Supplement: JOIM-283-356-s001.docx

The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth.

Umano GR et al.

The American Journal of Gastroenterology, 2018

GCKR polymorphism influences liver fat content in patients with type 2 diabetes.

Petit JM et al.

Acta Diabetologica, 2016

Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene.

Tan HL et al.

Journal of Gastroenterology, 2014

Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals.

Lin YC et al.

The American Journal of Clinical Nutrition, 2014

Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease.

Petta S et al.

Plos One, 2014

Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent.

Palmer ND et al.

Hepatology (baltimore, Md.), 2013

A common variant in the peroxisome proliferator-activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children.

Lin YC et al.

The American Journal of Clinical Nutrition, 2013

Genetic-related and carbohydrate-related factors affecting liver fat accumulation.

Goran MI et al.

Current Opinion in Clinical Nutrition and Metabolic Care, 2012

Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents.

Santoro N et al.

Hepatology (baltimore, Md.), 2012

Unraveling the genetics of fatty liver in obese children: additive effect of P446L GCKR and I148M PNPLA3 polymorphisms.

Valenti L et al.

Hepatology (baltimore, Md.), 2012

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.

Speliotes EK et al.

Plos Genetics, 2011

Genetic Analysis of Metabolic-associated Steatosis Liver Disease in a Colombian Cohort.

Prieto JE et al.

Journal of Clinical and Experimental Hepatology, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."