Associated Papers
Melanoma-Derived DNA Polymerase Theta Variants Exhibit Altered DNA Polymerase Activity.
Thomas C et al.
Biochemistry, 2024
The Impact of SNP-Induced Amino Acid Substitutions L19P and G66R in the dRP-Lyase Domain of Human DNA Polymerase β on Enzyme Activities.
Kladova OA et al.
International Journal of Molecular Sciences, 2024
Mouse models to explore the biological and organismic role of DNA polymerase beta.
Sobol RW
Environmental and Molecular Mutagenesis, 2024
The Role of Natural Polymorphic Variants of DNA Polymerase β in DNA Repair.
Kladova OA et al.
International Journal of Molecular Sciences, 2022
Defective DNA polymerase beta invoke a cytosolic DNA mediated inflammatory response.
Zhao S et al.
Frontiers in Immunology, 2022
Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Batra VK et al.
Biochemistry, 2020
Chromatin and other obstacles to base excision repair: potential roles in carcinogenesis.
Caffrey PJ et al.
Mutagenesis, 2020
Mutation in DNA Polymerase Beta Causes Spontaneous Chromosomal Instability and Inflammation-Associated Carcinogenesis in Mice.
Zhao S et al.
Cancers, 2019
Detection of Somatic Mutation in Exon 12 of DNA Polymerase β in Ovarian Cancer Tissue Samples
Khanra K et al.
Iranian Biomedical Journal, 2018
G648C variant of DNA polymerase β sensitizes esophageal cancer to chemotherapy.
Wang Y et al.
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2016
Overexpression of A613T and G462T variants of DNA polymerase β weakens chemotherapy sensitivity in esophageal cancer cell lines.
Wang Y et al.
Cancer Cell International, 2016
Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks.
Rozacky J et al.
Oncotarget, 2015
HeLa Cells Containing a Truncated Form of DNA Polymerase Beta are More Sensitized to Alkylating Agents than to Agents Inducing Oxidative Stress.
Khanra K et al.
Asian Pacific Journal of Cancer Prevention : Apjcp, 2015
The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.
Nemec AA et al.
The Journal of Biological Chemistry, 2014
Substrate rescue of DNA polymerase β containing a catastrophic L22P mutation.
Kirby TW et al.
Biochemistry, 2014
Cellular roles of DNA polymerase beta.
Ray S et al.
The Yale Journal of Biology and Medicine, 2013
Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.
Nemec AA et al.
The Journal of Biological Chemistry, 2012
Human POLB gene is mutated in high percentage of colorectal tumors.
Donigan KA et al.
The Journal of Biological Chemistry, 2012
The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator.
Murphy DL et al.
Biochemistry, 2012
The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation.
Donigan KA et al.
Dna Repair, 2012
Targeting DNA polymerase ß for therapeutic intervention.
Goellner EM et al.
Current Molecular Pharmacology, 2012
Association of two polymorphisms of DNA polymerase beta in exon-9 and exon-11 with ovarian carcinoma in India.
Khanra K et al.
Asian Pacific Journal of Cancer Prevention : Apjcp, 2012
Association of a newly identified variant of DNA polymerase beta (polβΔ63-123, 208-304) with the risk factor of ovarian carcinoma in India.
Khanra K et al.
Asian Pacific Journal of Cancer Prevention : Apjcp, 2012
Systematic biochemical analysis of somatic missense mutations in DNA polymerase β found in prostate cancer reveal alteration of enzymatic function.
An CL et al.
Human Mutation, 2011
The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient.
Dalal S et al.
Nucleic Acids Research, 2008
Is there a link between DNA polymerase beta and cancer?
Starcevic D et al.
Cell Cycle (georgetown, Tex.), 2004