Associated Papers
Unfilled gaps by polβ lead to aberrant ligation by LIG1 at the downstream steps of base excision repair pathway.
Gulkis M et al.
Nucleic Acids Research, 2024
DNA Polymerase β in the Context of Cancer.
Sawyer DL et al.
Critical Reviews in Oncogenesis, 2022
Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Batra VK et al.
Biochemistry, 2020
Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β.
Eckenroth BE et al.
Biochemistry, 2017
The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.
Nemec AA et al.
The Journal of Biological Chemistry, 2014
Cellular roles of DNA polymerase beta.
Ray S et al.
The Yale Journal of Biology and Medicine, 2013
Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.
Nemec AA et al.
The Journal of Biological Chemistry, 2012
Human POLB gene is mutated in high percentage of colorectal tumors.
Donigan KA et al.
The Journal of Biological Chemistry, 2012
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