Varaico: Literature-Extracted Genetic Variants

Gene:POLB
Variant:p.E249K
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POLB

NM_002690.3:p.E249K

Associated Papers

HeLa Cells Containing a Truncated Form of DNA Polymerase Beta are More Sensitized to Alkylating Agents than to Agents Inducing Oxidative Stress.

Khanra K et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2015

Loop II of DNA polymerase beta is important for discrimination during substrate binding.

Lin GC et al.

Dna Repair, 2009

The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding.

Murphy DL et al.

Biochemistry, 2008

Loop II of DNA polymerase beta is important for polymerization activity and fidelity.

Lin GC et al.

Nucleic Acids Research, 2007

Effect of DNA polymerase beta loop variants on discrimination of O6-methyldeoxyguanosine modification present in the nucleotide versus template substrate.

Hamid S et al.

Biochemistry, 2005

Is there a link between DNA polymerase beta and cancer?

Starcevic D et al.

Cell Cycle (georgetown, Tex.), 2004

The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site.

Dalal S et al.

The Journal of Biological Chemistry, 2004

The E249K mutator mutant of DNA polymerase beta extends mispaired termini.

Kosa JL et al.

The Journal of Biological Chemistry, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."