Varaico: Literature-Extracted Genetic Variants

Gene:POLB
Variant:p.Y265H
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POLB

NM_002690.3:p.Y265H

Associated Papers

DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.

Alnajjar KS et al.

Biochemistry, 2017

Conformational changes during normal and error-prone incorporation of nucleotides by a Y-family DNA polymerase detected by 2-aminopurine fluorescence.

DeLucia AM et al.

Biochemistry, 2007

Sequential side-chain residue motions transform the binary into the ternary state of DNA polymerase lambda.

Foley MC et al.

Biophysical Journal, 2006

Is there a link between DNA polymerase beta and cancer?

Starcevic D et al.

Cell Cycle (georgetown, Tex.), 2004

Gene structure, purification and characterization of DNA polymerase beta from Xiphophorus maculatus.

Oehlers LP et al.

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp, 2004

Variants of DNA polymerase Beta extend mispaired DNA due to increased affinity for nucleotide substrate.

Shah AM et al.

Biochemistry, 2003

Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity.

Shah AM et al.

The Journal of Biological Chemistry, 2001

The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells.

Clairmont CA et al.

Proceedings of the National Academy of Sciences of the United States of America, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."