Varaico: Literature-Extracted Genetic Variants

Gene:POLB
Variant:p.F272L
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POLB

NM_002690.3:p.F272L

Associated Papers

DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.

Alnajjar KS et al.

Biochemistry, 2017

Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta.

Yamtich J et al.

Biochemistry, 2010

Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities.

Shevelev I et al.

Nucleic Acids Research, 2003

Minor groove interactions at the DNA polymerase beta active site modulate single-base deletion error rates.

Osheroff WP et al.

The Journal of Biological Chemistry, 2000

Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.

Beard WA et al.

Mutation Research, 2000

Coupling ribose selection to fidelity of DNA synthesis. The role of Tyr-115 of human immunodeficiency virus type 1 reverse transcriptase.

Cases-Gonzalez CE et al.

The Journal of Biological Chemistry, 2000

The E249K mutator mutant of DNA polymerase beta extends mispaired termini.

Kosa JL et al.

The Journal of Biological Chemistry, 1999

Involvement of phenylalanine 272 of DNA polymerase beta in discriminating between correct and incorrect deoxynucleoside triphosphates.

Li SX et al.

Biochemistry, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."