Varaico: Literature-Extracted Genetic Variants

Gene:POLB
Variant:p.D276V
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POLB

NM_002690.3:p.D276V

Associated Papers

Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment.

Klvaňa M et al.

Biochemistry, 2012

The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding.

Murphy DL et al.

Biochemistry, 2008

DNA polymerase beta catalytic efficiency mirrors the Asn279-dCTP H-bonding strength.

Martínek V et al.

Febs Letters, 2007

Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses.

Yang L et al.

Biophysical Journal, 2004

[Study on DNA polymerase beta gene mutation in human cervical cancer].

Han LP et al.

Zhonghua Fu Chan Ke Za Zhi, 2003

DNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase beta. Implication for the identity of the rate-limiting conformational change.

Vande Berg BJ et al.

The Journal of Biological Chemistry, 2001

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."