Associated Papers
Comprehensive Analysis of Human Colorectal Cancers Harboring Polymerase Epsilon Mutations.
Gibson LM et al.
International Journal of Molecular Sciences, 2025
A redefined InDel taxonomy provides insights into mutational signatures.
Koh GCC et al.
Nature Genetics, 2025
Human DNA polymerase ε is a source of C>T mutations at CpG dinucleotides.
Tomkova M et al.
Nature Genetics, 2024
Signification and Application of Mutator and Antimutator Phenotype-Induced Genetic Variations in Evolutionary Adaptation and Cancer Therapeutics.
Chung WH
Journal of Microbiology (seoul, Korea), 2023
DNA mismatch repair protects the genome from oxygen-induced replicative mutagenesis.
Lózsa R et al.
Nucleic Acids Research, 2023
Replication DNA polymerases, genome instability and cancer therapies.
Strauss JD et al.
Nar Cancer, 2023
Candidate variants in DNA replication and repair genes in early-onset renal cell carcinoma patients referred for germline testing.
Demidova EV et al.
Bmc Genomics, 2023
Case Report: Cancer spectrum and genetic characteristics of a de novo germline POLD1 p.L606M variant-induced polyposis syndrome.
Zhang Y et al.
Frontiers in Oncology, 2023
Scrutinizing Deleterious Nonsynonymous SNPs and Their Effect on Human POLD1 Gene.
Bappy MNI et al.
Genetics Research, 2022
POLE, POLD1, and NTHL1: the last but not the least hereditary cancer-predisposing genes.
Magrin L et al.
Oncogene, 2021
Additive effects of variants of unknown significance in replication repair-associated DNA polymerase genes on mutational burden and prognosis across diverse cancers.
Ying J et al.
Journal for Immunotherapy of Cancer, 2021
POLE/POLD1 mutation in non-exonuclease domain matters for predicting efficacy of immune-checkpoint-inhibitor therapy.
Chen YX et al.
Clinical and Translational Medicine, 2021
Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.
Soriano I et al.
Plos Genetics, 2021
Genomic Profiling Reveals the Molecular Landscape of Gastrointestinal Tract Cancers in Chinese Patients.
Zhu C et al.
Frontiers in Genetics, 2021
Role of POLE and POLD1 in familial cancer.
Mur P et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2020
DNA Polymerases at the Eukaryotic Replication Fork Thirty Years after: Connection to Cancer.
Pavlov YI et al.
Cancers, 2020
The POLD1R689W variant increases the sensitivity of colorectal cancer cells to ATR and CHK1 inhibitors.
Job A et al.
Scientific Reports, 2020
Comprehensive Analysis of Hypermutation in Human Cancer.
Campbell BB et al.
Cell, 2017
Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells.
Mertz TM et al.
Oncogene, 2017
Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.
Barbari SR et al.
Dna Repair, 2017
Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies.
Berg KCG et al.
Molecular Cancer, 2017
POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies.
Nicolas E et al.
Gene, 2016
Deoxyribonucleotide metabolism, mutagenesis and cancer.
Mathews CK
Nature Reviews. Cancer, 2015
Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity.
Mertz TM et al.
Proceedings of the National Academy of Sciences of the United States of America, 2015
Structural insights into eukaryotic DNA replication.
Doublié S et al.
Frontiers in Microbiology, 2014
DNA replication fidelity and cancer.
Preston BD et al.
Seminars in Cancer Biology, 2010
A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.
Daee DL et al.
Proceedings of the National Academy of Sciences of the United States of America, 2010