Varaico: Literature-Extracted Genetic Variants

Gene:POLE
Variant:p.V533M
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POLE

NM_006231.4:p.V533M

Associated Papers

A phase II clinical trial of toripalimab in advanced solid tumors with polymerase epsilon/polymerase delta (POLE/POLD1) mutation.

Jin Y et al.

Signal Transduction and Targeted Therapy, 2024

Hereditary variants of unknown significance in African American women with breast cancer.

McDonald JT et al.

Plos One, 2022

36315513 (PubMed )
Supplement: pone.0273835.s001.xlsx › ConsensusScores

Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene.

Hino H et al.

Cancer Medicine, 2019

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

Temko D et al.

The Journal of Pathology, 2018

29604063 (PubMed )
Supplement: PATH-245-283-s023.xlsx › lumc_supp_drivers_edited_1.1
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."