Varaico: Literature-Extracted Genetic Variants

Gene:POLE
Variant:p.L439V
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POLE

NM_006231.4:p.L439V

Associated Papers

Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variants.

Selves J et al.

Life Science Alliance, 2024

Replication DNA polymerases, genome instability and cancer therapies.

Strauss JD et al.

Nar Cancer, 2023

Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels.

Barbari SR et al.

Nucleic Acids Research, 2022

Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles.

Herzog M et al.

Nucleic Acids Research, 2021

Genetic, structural, and functional characterization of POLE polymerase proofreading variants allows cancer risk prediction.

Hamzaoui N et al.

Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2020

Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae.

Barbari SR et al.

G3 (bethesda, Md.), 2018

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."