Associated Papers
Phenotypic POLE Variant Classification Identifies Patients Who May Have Favorable Prognosis and Benefit from Immunotherapy.
Keller-Evans RB et al.
The Journal of Molecular Diagnostics : Jmd, 2026
Integrating evidence from protein domains to identify cancer driver mutations.
Ostroverkhova D et al.
Protein Science : a Publication of the Protein Society, 2026
Common gene mutations in 103 authenticated colorectal cancer cell lines.
Kranjec C et al.
Oncogenesis, 2026
The clinical landscape of POLE-mutant colorectal cancer: a retrospective analysis of real-world outcome.
Xu T et al.
Bmc Medicine, 2026
Preanalytical Histology Review Improves POLE Mutation Detection in Endometrial Carcinomas.
Huang H et al.
The Journal of Molecular Diagnostics : Jmd, 2026
Comparative Analysis of Somatic and Germline Polymerase Proofreading Deficiencies in Cancer: Molecular and Clinical Implications.
Viana-Errasti J et al.
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2025
Distinct genomic subgroups and mutational patterns in undifferentiated/dedifferentiated endometrial carcinoma.
Huang CY et al.
Bmc Cancer, 2025
Comparison between a Luminex-based multiplex kit with a sequence-specific oligonucleotide probe and next-generation sequencing for the detection of POLE oncogenic mutations in endometrial cancer.
Kato MK et al.
Virchows Archiv : an International Journal of Pathology, 2025
Comprehensive Analysis of Human Colorectal Cancers Harboring Polymerase Epsilon Mutations.
Gibson LM et al.
International Journal of Molecular Sciences, 2025
Colorectal Tumors in Diverse Patient Populations Feature a Spectrum of Somatic Mutational Profiles.
Matejcic M et al.
Cancer Research, 2025
Functions, interactions and prognostic role of POLE: a bioinformatics analysis.
Carvajal-Veloza J et al.
Journal of Gynecologic Oncology, 2025
Genetics, genomics and clinical features of adenomatous polyposis.
Joo JE et al.
Familial Cancer, 2025
Understanding the impact of spatial immunophenotypes on the survival of endometrial cancer patients through the ProMisE classification.
Hattori S et al.
Cancer Immunology, Immunotherapy : Cii, 2025
Morphomolecular Correlation and Clinicopathologic Analysis in Endometrial Carcinoma.
Bülbül G et al.
International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists, 2024
Human DNA polymerase ε is a source of C>T mutations at CpG dinucleotides.
Tomkova M et al.
Nature Genetics, 2024
Evaluation of the Accuracy of a Polymerase Chain Reaction-Based Assay for Polymerase Tifilon Mutation Detection in Endometrial Carcinoma.
Chen T et al.
Archives of Pathology & Laboratory Medicine, 2024
Morules and β-catenin predict POLE mutation status in endometrial cancer: A pathway to more cost-effective diagnostic procedures.
Fan R et al.
American Journal of Clinical Pathology, 2024
Endometrial carcinoma: 10 years of TCGA (the cancer genome atlas): A critical reappraisal with comments on FIGO 2023 staging.
Espinosa I et al.
Gynecologic Oncology, 2024
Immune checkpoint inhibitors for POLE or POLD1 proofreading-deficient metastatic colorectal cancer.
Ambrosini M et al.
Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2024
DNA mismatch and damage patterns revealed by single-molecule sequencing.
Liu MH et al.
Nature, 2024
Deep learning for dual detection of microsatellite instability and POLE mutations in colorectal cancer histopathology.
Gustav M et al.
Npj Precision Oncology, 2024
Spectrum of somatic mutational features of colorectal tumors in ancestrally diverse populations.
Matejcic M et al.
Medrxiv : the Preprint Server for Health Sciences, 2024
Specific Pathology Features Enrich Selection of Endometrial Carcinomas for POLE Testing.
Keyhanian K et al.
The American Journal of Surgical Pathology, 2024
Exploring Co-occurring POLE Exonuclease and Non-exonuclease Domain Mutations and Their Impact on Tumor Mutagenicity.
Shah SM et al.
Cancer Research Communications, 2024
DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors.
Ostroverkhova D et al.
Cell Reports, 2024
Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variants.
Selves J et al.
Life Science Alliance, 2024
The Clinical and Pathological Characteristics of POLE-Mutated Endometrial Cancer: A Comprehensive Review.
Yao X et al.
Cancer Management and Research, 2024
The game-changing impact of POLE mutations in oncology-a review from a gynecologic oncology perspective.
Kögl J et al.
Frontiers in Oncology, 2024
Validation of Modaplex POLE mutation assay in endometrial carcinoma.
Dorca E et al.
Virchows Archiv : an International Journal of Pathology, 2023
Rare germline variants in POLE and POLD1 encoding the catalytic subunits of DNA polymerases ε and δ in glioma families.
Weber CAM et al.
Acta Neuropathologica Communications, 2023
Recommendations for the classification of germline variants in the exonuclease domain of POLE and POLD1.
Mur P et al.
Genome Medicine, 2023
Replication DNA polymerases, genome instability and cancer therapies.
Strauss JD et al.
Nar Cancer, 2023
Harmonized molecular classification; assessment of a single-test ProMisE NGS tool.
Jamieson A et al.
Gynecologic Oncology, 2023
Histomorphological and molecular genetic characterization of different intratumoral regions and matched metastatic lymph nodes of colorectal cancer with heterogenous mismatch repair protein expression.
Zhang J et al.
Journal of Cancer Research and Clinical Oncology, 2023
POLE-Mutant Colon Cancer Treated with PD-1 Blockade Showing Clearance of Circulating Tumor DNA and Prolonged Disease-Free Interval.
Bikhchandani M et al.
Genes, 2023
QPOLE: A Quick, Simple, and Cheap Alternative for POLE Sequencing in Endometrial Cancer by Multiplex Genotyping Quantitative Polymerase Chain Reaction.
Van den Heerik ASVM et al.
Jco Global Oncology, 2023
Utility of molecular subtypes and genetic alterations for evaluating clinical outcomes in 1029 patients with endometrial cancer.
Asami Y et al.
British Journal of Cancer, 2023
ProTarget: a Danish Nationwide Clinical Trial on Targeted Cancer Treatment based on genomic profiling - a national, phase 2, prospective, multi-drug, non-randomized, open-label basket trial.
Kringelbach T et al.
Bmc Cancer, 2023
Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing.
Liu MH et al.
Biorxiv : the Preprint Server for Biology, 2023