Varaico: Literature-Extracted Genetic Variants

Gene:POLE
Variant:p.I300I
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POLE

NM_006231.4:p.I300I

Associated Papers

The clinical utility of next generation sequencing in endometrial cancer: focusing on molecular subtyping and lynch syndrome.

Guo Y et al.

Frontiers in Genetics, 2024

Functional pre-therapeutic evaluation by genome editing of variants of uncertain significance of essential tumor suppressor genes.

Billaud A et al.

Genome Medicine, 2021

34749799 (PubMed )
Supplement: 13073_2021_976_MOESM1_ESM.pdf

Clinically relevant molecular subtypes and genomic alteration-independent differentiation in gynecologic carcinosarcoma.

Gotoh O et al.

Nature Communications, 2019

31672974 (PubMed )
Supplement: 41467_2019_12985_MOESM8_ESM.xlsx › Suppl_Data_5

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

Temko D et al.

The Journal of Pathology, 2018

29604063 (PubMed )
Supplement: PATH-245-283-s021.xlsx › EC.Drivers.Edited
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."