Varaico: Literature-Extracted Genetic Variants

Gene:POLE
Variant:p.A11E
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POLE

NM_006231.4:p.A11E

Associated Papers

Comprehensive Analysis of Human Colorectal Cancers Harboring Polymerase Epsilon Mutations.

Gibson LM et al.

International Journal of Molecular Sciences, 2025

40806338 (PubMed )
Supplement: ijms-26-07208-s001.zip › Table_S1.xlsx › S1A_COSMIC_mutation

Computational image and molecular analysis reveal unique prognostic features of immune architecture in African Versus European American women with endometrial cancer.

Azarianpour S et al.

Npj Precision Oncology, 2025

40550926 (PubMed )
Supplement: 41698_2025_972_MOESM2_ESM.xlsx › Supplementary_Data_S1

Recommendations for the classification of germline variants in the exonuclease domain of POLE and POLD1.

Mur P et al.

Genome Medicine, 2023

37848928 (PubMed )
Supplement: 13073_2023_1234_MOESM6_ESM.xlsx › Table_S6

Tumor collagens predict genetic features and patient outcomes.

Guo KS et al.

Npj Genomic Medicine, 2023

37414817 (PubMed )
Supplement: 41525_2023_358_MOESM3_ESM.xlsx › UCEC

In-silico analysis of TCGA data showing multiple POLE-like favourable subgroups overlapping with TP53 mutated endometrial cancer: Implications for clinical practice in low and middle-income countries.

Das Ghosh D et al.

Gynecologic Oncology Reports, 2023

37293351 (PubMed )
Supplement: mmc2.xlsx › MSI

Detection and characterization of constitutive replication origins defined by DNA polymerase epsilon.

Jaksik R et al.

Bmc Biology, 2023

36829160 (PubMed )
Supplement: 12915_2023_1527_MOESM1_ESM.xlsx › Tab1

POLE/POLD1 mutation in non-exonuclease domain matters for predicting efficacy of immune-checkpoint-inhibitor therapy.

Chen YX et al.

Clinical and Translational Medicine, 2021

34586735 (PubMed )
Supplement: CTM2-11-e524-s001.xlsx › Supplementary_Table_2

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.

Fang H et al.

Plos Genetics, 2020

32012149 (PubMed )
Supplement: pgen.1008572.s015.xlsx › Supplementary_table_6

The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy.

Ahn SM et al.

Oncotarget, 2016

27612425 (PubMed )
Supplement: oncotarget-07-68638-s005.xlsx › Sheet1

Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations.

Hussein YR et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2015

DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer.

Church DN et al.

Human Molecular Genetics, 2013

23528559 (PubMed )
Supplement: supp_ddt131_ddt131supp.pdf
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."