Varaico: Literature-Extracted Genetic Variants

Gene:POLE
Variant:p.R4S
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POLE

NM_006231.4:p.R4S

Associated Papers

Exploratory biomarkers for oxaliplatin-induced nivolumab responsiveness in metastatic microsatellite-stable colorectal cancer.

Ree AH et al.

British Journal of Cancer, 2026

Advances in immunotherapy for colorectal cancer: overcoming resistance in mismatch repair-proficient tumors.

Keivany MR et al.

Cancer Cell International, 2026

Oral Melanocytic Neoplasms: A Narrative Review.

Maldonado-Mendoza J

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2025

Distinct Driver Pathway Enrichments and a High Prevalence of TSC2 Mutations in Right Colon Cancer in Chile: A Preliminary Comparative Analysis.

Tapia-Valladares C et al.

International Journal of Molecular Sciences, 2024

38731914 (PubMed )
Supplement: ijms-25-04695-s001.zip › ijms-2890573-supplementary.pdf

Japanese Society of Medical Oncology clinical guidelines: Molecular testing for colorectal cancer treatment, 5th edition.

Bando H et al.

Cancer Science, 2024

38263580 (PubMed )
Supplement: CAS-115-1014-s001.docx

Molecular profiling and feasibility using a comprehensive hybrid capture panel on a consecutive series of non-small-cell lung cancer patients from a single centre.

Mosteiro M et al.

Esmo Open, 2023

Mesonephric-like adenocarcinoma of the female genital tract: possible role of KRAS-targeted treatment-detailed molecular analysis of a case series and review of the literature for targetable somatic KRAS-mutations.

Brambs CE et al.

Journal of Cancer Research and Clinical Oncology, 2023

Prognosis and Characterization of Microenvironment in Cervical Cancer Influenced by Fatty Acid Metabolism-Related Genes.

Zhou Y et al.

Journal of Oncology, 2023

Potential genetic biomarker of Saudi Arabian patients with colorectal cancer.

Younis NS et al.

European Review for Medical and Pharmacological Sciences, 2022

Genomic correlates of response and resistance to immune checkpoint inhibitors in carcinomas of unknown primary.

Rassy E et al.

European Journal of Clinical Investigation, 2021

Genomic profiling of primary histiocytic sarcoma reveals two molecular subgroups.

Egan C et al.

Haematologica, 2020

Clinical impact of endometrial cancer stratified by genetic mutational profiles, POLE mutation, and microsatellite instability.

Haruma T et al.

Plos One, 2018

KRAS and PIK3CA mutations in colorectal adenocarcinomas correlate with aggressive histological features and behavior.

Jang S et al.

Human Pathology, 2017

Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma.

Dong ZY et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2017

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."