Associated Papers
Small molecules restore mutant mitochondrial DNA polymerase activity.
Valenzuela S et al.
Nature, 2025
40205042 (PubMed )
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Engineering mtDNA deletions by reconstituting end joining in human mitochondria.
Fu Y et al.
Cell, 2025
The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability.
Forslund JME et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
Engineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria.
Fu Y et al.
Biorxiv : the Preprint Server for Biology, 2024
The Fate of Oxidative Strand Breaks in Mitochondrial DNA.
Trombly G et al.
Antioxidants (basel, Switzerland), 2023
The 5'-phosphate enhances the DNA-binding and exonuclease activities of human mitochondrial genome maintenance exonuclease 1 (MGME1).
Urrutia KM et al.
The Journal of Biological Chemistry, 2022
DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.
Silva-Pinheiro P et al.
Nucleic Acids Research, 2021
Deep sequencing of mitochondrial DNA and characterization of a novel POLG mutation in a patient with arPEO.
Hedberg-Oldfors C et al.
Neurology. Genetics, 2020
Mechanisms of Mitochondrial DNA Deletion Formation.
Nissanka N et al.
Trends in Genetics : Tig, 2019
Mitochondrial DNA degradation: A quality control measure for mitochondrial genome maintenance and stress response.
Zhao L
The Enzymes, 2019
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery.
Peeva V et al.
Nature Communications, 2018
The presence of rNTPs decreases the speed of mitochondrial DNA replication.
Forslund JME et al.
Plos Genetics, 2018
Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain.
Taylor SD et al.
Aging Cell, 2014
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