Associated Papers
Effects of Rare Coding Variants in Severe Early-Onset Obesity Genes in the Population-Based UK Biobank Study.
Jia RY et al.
The Journal of Clinical Endocrinology and Metabolism, 2025
Exome sequencing reveals new insights into the germline landscape of inflammatory breast cancer among Tunisian patients.
Boujemaa M et al.
Journal of Translational Medicine, 2025
Medical semiology of patients with monogenic obesity: A systematic review.
Renard E et al.
Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 2024
Type 2 Diabetes Remission in Patients with Heterozygous Variants in the Leptin-Melanocortin Pathway after Roux-en-Y Gastric Bypass: A Matched Case-Control Study.
Anazco D et al.
Obesity Surgery, 2023
Genomic variants exclusively identified in children with birth defects and concurrent malignant tumors predispose to cancer development.
Liu Y et al.
Molecular Cancer, 2023
Functional characterization of all missense variants in LEPR, PCSK1, and POMC genes arising from single-nucleotide variants.
Shah BP et al.
Expert Review of Endocrinology & Metabolism, 2023
Implication of Heterozygous Variants in Genes of the Leptin-Melanocortin Pathway in Severe Obesity.
Courbage S et al.
The Journal of Clinical Endocrinology and Metabolism, 2021
Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment.
Ayers KL et al.
The Journal of Clinical Endocrinology and Metabolism, 2018
Next-generation sequencing of the monogenic obesity genes LEP, LEPR, MC4R, PCSK1 and POMC in a Norwegian cohort of patients with morbid obesity and normal weight controls.
Nordang GBN et al.
Molecular Genetics and Metabolism, 2017
The neuroendocrine circuitry controlled by POMC, MSH, and AGRP.
Biebermann H et al.
Handbook of Experimental Pharmacology, 2012
The role of leptin-melanocortin system and human weight regulation: lessons from experiments of nature.
Lee YS
Annals of the Academy of Medicine, Singapore, 2009
Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain.
Dubern B et al.
Pediatric Research, 2008
The role of melanocortin 3 receptor gene in childhood obesity.
Lee YS et al.
Diabetes, 2007
The molecular genetics of the melanocortin pathway and energy homeostasis.
Leibel RL
Cell Metabolism, 2006
A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance.
Lee YS et al.
Cell Metabolism, 2006
Investigating genetic variants in early-onset obesity through exome sequencing: A retrospective cohort study.
Liu D et al.
Obesity Research & Clinical Practice, 0