Associated Papers
Functional integrity of the SEL1L-HRD1 complex is critical for endoplasmic reticulum-associated degradation and organismal viability.
Zhang X et al.
Proceedings of the National Academy of Sciences of the United States of America, 2026
Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.
Lin LL et al.
Nature Communications, 2026
Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation.
Pan X et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2025
PINK1 controls RTN3L-mediated ER autophagy by regulating peripheral tubule junctions.
Chidambaram R et al.
The Journal of Cell Biology, 2024
RTN3L and CALCOCO1 function in parallel to maintain proteostasis in the endoplasmic reticulum.
Kumar K et al.
Autophagy, 2024
Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: Implication for MC4R agonist use.
Le Collen L et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2023
Functional characterization of all missense variants in LEPR, PCSK1, and POMC genes arising from single-nucleotide variants.
Shah BP et al.
Expert Review of Endocrinology & Metabolism, 2023
Unraveling the roles of endoplasmic reticulum-associated degradation in metabolic disorders.
Luo H et al.
Frontiers in Endocrinology, 2023
Endoplasmic reticulum tubules limit the size of misfolded protein condensates.
Parashar S et al.
Elife, 2021
Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity.
Chiurazzi M et al.
International Journal of Molecular Sciences, 2020
Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions.
Xu L et al.
Nature Cell Biology, 2020
Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates.
Cunningham CN et al.
Molecular Cell, 2019
Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment.
Ayers KL et al.
The Journal of Clinical Endocrinology and Metabolism, 2018
Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity.
Kim GH et al.
The Journal of Clinical Investigation, 2018
Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway.
Creemers JW et al.
The Journal of Clinical Endocrinology and Metabolism, 2008
[Genetic variations in energy balance regulation].
Pankov IuA
Biomeditsinskaia Khimiia, 0