Varaico: Literature-Extracted Genetic Variants

Gene:PON1
Variant:p.Q192R
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PON1

NM_000446.7:p.Q192R

Associated Papers

A Pilot Study Exploring Paraoxonase-1 Tissue Protein Expression and Circulating Levels in Bladder Cancer.

Parada D et al.

Antioxidants (basel, Switzerland), 2026

Genetic Determinants of Coronary Artery Disease in Type 2 Diabetes Mellitus Among Asian Populations: A Meta-Analysis.

Kabibulatova A et al.

Medical Sciences (basel, Switzerland), 2026

Unveiling the Neuroprotective Effect of Paraoxonase 1 in Neurodegenerative Diseases Focusing on Alzheimer's Disease.

Ismail A et al.

Molecular Neurobiology, 2025

Newborn MTHFR rs1801133 Variant and Extremely Low Birth Weight: A Case-Control Study and Meta-Analysis.

Skulimowski B et al.

Genes, 2025

Single Nucleotide Polymorphisms in Oxidative Stress-Related Genes Are Associated with Autism Spectrum Disorders.

Spoto G et al.

International Journal of Molecular Sciences, 2025

Integrative pharmacogenomics analysis predicts the platelet response in clopidogrel treated coronary artery disease (CAD) patients of South India.

Bharath G et al.

Scientific Reports, 2025

Impact of SNP Variants in PON-1 or UGT1A1 on Iron Chelation Therapy Outcomes and Zinc Status in Thalassemia Major Patients.

Lu MY et al.

Biological Trace Element Research, 2025

Potential risk genotypes associated with symptoms of pesticide poisoning based on polymorphisms in the XRCC1 (rs25487 and rs1799782), SOD2 (rs4880), PON1 (rs662) and GSTP1 (rs1695) genes, in farmers in the Cienega region.

Flores Gutiérrez CA et al.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research, 2025

A narrative review of research advancements in pharmacogenetics of cardiovascular disease and impact on clinical implications.

Shorbaji A et al.

Npj Genomic Medicine, 2025

Paraoxonase 1 polymorphisms and their relationship with gastric cancer risk: a biochemical perspective on oxidative stress.

Najafi E et al.

Molecular Biology Reports, 2025

Association of CETP, APOA5, IL6, and PON1 Gene Variants with Dyslipidemia and Cardiovascular Risk in a Population from Cauca Department, Colombia.

Urbano-Cano AL et al.

Genes, 2025

Pon1 and Sult1a1 Polymorphisms and Breast Cancer Among Young Women in Brazil.

da Costa RSS et al.

Journal of Adolescent and Young Adult Oncology, 2025

Dantrolene is an HDL-associated paraoxonase-1 activator with immunosuppressive and atheroprotective properties.

Dedemadi AG et al.

Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids, 2025

Proteogenomic Profiling of Treatment-Naïve Metastatic Malignant Melanoma.

Kuras M et al.

Cancers, 2025

40075679 (PubMed )
Supplement: cancers-17-00832-s001.zip › Table_S5._SAAVs.xlsx › Table_S5A

Association of paraoxonase-1 (Q192R) gene polymorphism with coronary artery spasm during cardiac catheterisation in Egyptians.

Abdelaziz TA et al.

Archives of Physiology and Biochemistry, 2025

Identifying genetic susceptibility loci associated with human coronary artery disease.

Zahid A et al.

Plos One, 2025

Advances in the Clinical Use of Clopidogrel: A Review of Individualized Treatment Strategies and Monitoring Optimization Based on Genetic Polymorphisms.

Dou N et al.

Pharmacogenomics and Personalized Medicine, 2025

Molecular Structure of Paraoxonase-1 and Its Modifications in Relation to Enzyme Activity and Biological Functions-A Comprehensive Review.

Lewoń-Mrozek D et al.

International Journal of Molecular Sciences, 2024

The importance of paraoxonase 1 activity in chronic kidney disease.

Samouilidou EC et al.

Renal Failure, 2024

Determination of selected oxysterol levels, oxidative stress, and macrophage activation indicators in children and adolescents with familial hypercholesterolemia.

Canbay E et al.

Lipids in Health and Disease, 2024

39538217 (PubMed )
Supplement: 12944_2024_2371_MOESM3_ESM.pdf

The Molecular Bases of Anti-Oxidative and Anti-Inflammatory Properties of Paraoxonase 1.

Jakubowski H

Antioxidants (basel, Switzerland), 2024

Regulation of Human Hydrolases and Its Implications in Pharmacokinetics and Pharmacodynamics.

Jung SM et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2024

The associations between single nucleotide polymorphisms and diabetic retinopathy risk: an umbrella review.

Huang S et al.

Endocrine Journal, 2024

The Association of the Cholesterol Efflux Capacity with the Paraoxonase 1 Q192R Genotype and the Paraoxonase Activity.

Oniki K et al.

Journal of Atherosclerosis and Thrombosis, 2024

Genetic Determinants of High-density Lipoprotein Cholesterol Efflux Capacity: Insights from Paraoxonase 1 Polymorphisms.

Toh R

Journal of Atherosclerosis and Thrombosis, 2024

A Case-Control Study Supports Genetic Contribution of the PON Gene Family in Obesity and Metabolic Dysfunction Associated Steatotic Liver Disease.

Van Dijck E et al.

Antioxidants (basel, Switzerland), 2024

PON1 rs662, rs854560 and TRIB1 rs17321515, rs2954029 Gene Polymorphisms Are Associated with Lipid Parameters in Patients with Unstable Angina.

Malinowski D et al.

Genes, 2024

Phospholipid metabolism-related genotypes of PLA2R1 and CERS4 contribute to nonobese MASLD.

Shao C et al.

Hepatology Communications, 2024

PON1, APOE and SDF-1 Gene Polymorphisms and Risk of Retinal Vein Occlusion: A Case-Control Study.

Ragkousis A et al.

Genes, 2024

Association of PON1, APOE and SDF-1 Gene Polymorphisms with Treatment Response to Intravitreal Anti-VEGF Treatment in Patients with Retinal Vein Occlusion.

Ragkousis A et al.

Seminars in Ophthalmology, 2024

Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview.

Perini JA et al.

Toxics, 2024

38535959 (PubMed )
Supplement: toxics-12-00226-s001.zip › toxics-2905208-supplementary.pdf

The diversity and clinical implications of genetic variants influencing clopidogrel bioactivation and response in the Emirati population.

Khasawneh LQ et al.

Human Genomics, 2024

Gene-environment interactions and preterm birth predictors: A Bayesian network approach.

Elias DE et al.

Genetics and Molecular Biology, 2024

The Regulatory Variant -108C/T in the Promoter of Paraoxonase 1 (PON1) Gene has a More Important Role in Regulating PON1 Activity Compared to rs3735590 in 3'-UTR in Patients with Coronary Artery Disease.

Zargari M et al.

Advanced Biomedical Research, 2024

Polymorphism rs662 (Q192R) of paraoxonase-1 and susceptibility to atherosclerosis of the coronary arteries.

Baranska M et al.

Archives of Medical Science : Ams, 2024

Personalization of clopidogrel therapy based on genetic polymorphism analysis: clinical implications.

Chen S et al.

American Journal of Translational Research, 2024

Cytochrome P-450 CYP2C19 genetic polymorphism and its relation with clopidogrel resistance.

Nawaz U et al.

Jpma. the Journal of the Pakistan Medical Association, 2023

Genetic association between vitamin D receptor gene and Saudi patients confirmed with Familial Hypercholesterolemia.

Al-Nbaheen MS

Acta Biochimica Polonica, 2023

Serum Arylesterase, Paraoxonase, and Lactonase Activities and Paraoxonase-1 Concentrations in Morbidly Obese Patients and Their Relationship with Non-Alcoholic Steatohepatitis.

Castañé H et al.

Antioxidants (basel, Switzerland), 2023

Structural Characteristics of PON1 with Leu55Met and Gln192Arg Variants Influencing Oxidative-Stress-Related Diseases: An Integrated Molecular Modeling and Dynamics Study.

M S et al.

Medicina (kaunas, Lithuania), 2023

CDKN2B-AS (rs2891168), SOD2 (rs4880), and PON1 (rs662) polymorphisms and susceptibility to coronary artery disease and type 2 diabetes mellitus in Iranian patients: A case-control study.

Yari A et al.

Health Science Reports, 2023

The associations of PON1 and APOE polymorphisms with plasma lipid levels and the risk for late complications in type 2 diabetes patients.

Klen J et al.

Journal of Medical Biochemistry, 2023

The Incidence of the XRCC1 rs25487 and PON1 rs662 Polymorphisms in a Population from Central Brazil: Patterns in an Area with a High Level of Agricultural Activity.

Alves AA et al.

Biochemical Genetics, 2023

The association of paraoxonase I gene polymorphisms Q192R (rs662) and L55M (rs854560) and its activity with metabolic syndrome components in fars ethnic group.

Marjani A et al.

Hormone Molecular Biology and Clinical Investigation, 2023

Deficit schizophrenia and its features are associated with PON1 Q192R genotypes and lowered paraoxonase 1 (PON1) enzymatic activity: effects on bacterial translocation - Corrigendum.

Matsumoto AK et al.

Cns Spectrums, 2023

Pharmacogenomics of response to statin treatment and susceptibility to statin-induced adverse drug reactions in Asians: a scoping review.

Yow HY et al.

Asian Biomedicine : Research, Reviews and News, 2023

Role of paraoxonase 1 activity and PON1 gene polymorphisms in sickle cell disease.

Menezes JF et al.

Scientific Reports, 2023

Proteomic Exploration of Paraoxonase 1 Function in Health and Disease.

Jakubowski H

International Journal of Molecular Sciences, 2023

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."